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CG5254 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31020, updated on 4-Jan-2025

Summary

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Official Symbol
CG5254provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0040383
Locus tag
Dmel_CG5254
See related
AllianceGenome:FB:FBgn0040383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CT16777; Dmel\CG5254; EG:BACR19J1.2
Summary
Predicted to enable alpha-ketoglutarate transmembrane transporter activity. Predicted to be involved in mitochondrial alpha-ketoglutarate transmembrane transport. Predicted to be located in mitochondrial inner membrane. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval fat body; and yolk nucleus. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 18. Orthologous to human SLC25A21 (solute carrier family 25 member 21). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG5254 in Genome Data Viewer
Location:
1C3-1C4; 1-0 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (750347..758719)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (644380..652752)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene sidekick Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44965 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells. Valsecchi CIK, et al. Nat Commun, 2018 Sep 7. PMID 30194291, Free PMC Article
  2. Phylogenetic Analysis Guides Transporter Protein Deorphanization: A Case Study of the SLC25 Family of Mitochondrial Metabolite Transporters. Byrne KL, et al. Biomolecules, 2023 Aug 28. PMID 37759714, Free PMC Article
  3. Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers. Curcio R, et al. Int J Mol Sci, 2020 Aug 22. PMID 32842667, Free PMC Article
  4. Genetic Basis of Increased Lifespan and Postponed Senescence in Drosophila melanogaster. Parker GA, et al. G3 (Bethesda), 2020 Mar 5. PMID 31969430, Free PMC Article
  5. A SAGE approach to discovery of genes involved in autophagic cell death. Gorski SM, et al. Curr Biol, 2003 Feb 18. PMID 12593804

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-ketoglutarate transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial alpha-ketoglutarate transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5254-PA
CG5254-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    750347..758719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297830.1 → NP_001284759.1  uncharacterized protein Dmel_CG5254, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284759.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JA11
    Conserved Domains (1) summary
    pfam00153
    Location:140 → 236
    Mito_carr; Mitochondrial carrier protein

  2. NM_130500.4 → NP_569856.2  uncharacterized protein Dmel_CG5254, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569856.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3T2
    Related
    FBpp0070129
    Conserved Domains (2) summary
    PTZ00169
    Location:19 → 301
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:18 → 112
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SZN6 Q8SZN6
Q9V3T2 Q9V3T2
X2JA11 X2JA11

Gene LinkOut

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