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Mier3 MIER family member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310086, updated on 2-Nov-2024

Summary

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Official Symbol
Mier3provided by RGD
Official Full Name
MIER family member 3provided by RGD
Primary source
RGD:1311241
See related
EnsemblRapid:ENSRNOG00000013121 AllianceGenome:RGD:1311241
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311241
Summary
Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Orthologous to human MIER3 (MIER family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 158.8), Spleen (RPKM 114.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mier3 in Genome Data Viewer
Location:
2q14
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (45021167..45049745)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (43287546..43316422)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (43266301..43295175)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 68 Neighboring gene uncharacterized LOC134485835 Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene Neighboring gene SET domain containing, pseudogene 1 Neighboring gene uncharacterized LOC134485836

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MIER3 suppresses the progression of non-small cell lung cancer by inhibiting Wnt/β-Catenin pathway and histone acetyltransferase activity. Zhang H, et al. Transl Cancer Res, 2020 Jan. PMID 35117188, Free PMC Article
  2. MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail. Huang W, et al. Exp Cell Res, 2021 Sep 1. PMID 34242623
  3. Differential HDAC1 and 2 Recruitment by Members of the MIER Family. Derwish R, et al. PLoS One, 2017. PMID 28046085, Free PMC Article
  4. Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene. denDekker AD, et al. Cancer Res, 2012 Nov 15. PMID 22993404, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT contributes_to histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mesoderm induction early response protein 3
Names
mesoderm induction early response 1, family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168000.2 → NP_001161472.1  mesoderm induction early response protein 3

    See identical proteins and their annotated locations for NP_001161472.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6I5N1, D3ZE77
    Conserved Domains (2) summary
    cd11661
    Location:255 → 299
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:149 → 197
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    45021167..45049745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231925.4 → XP_006231987.3  mesoderm induction early response protein 3 isoform X2

    UniProtKB/TrEMBL
    A6I5N1

  2. XM_006231924.5 → XP_006231986.1  mesoderm induction early response protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUL8, D3ZE77
    Related
    ENSRNOP00000069147.1, ENSRNOT00000087031.3
    Conserved Domains (3) summary
    smart00717
    Location:280 → 327
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:282 → 326
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:176 → 224
    ELM2; ELM2 domain

  3. XM_039102181.2 → XP_038958109.1  mesoderm induction early response protein 3 isoform X2

    UniProtKB/TrEMBL
    A6I5N1, D3ZE77
    Conserved Domains (2) summary
    cd11661
    Location:255 → 299
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:149 → 197
    ELM2; ELM2 domain

  4. XM_063281723.1 → XP_063137793.1  mesoderm induction early response protein 3 isoform X2

    UniProtKB/TrEMBL
    A6I5N1

RNA

  1. XR_010063601.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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