Dna2 DNA replication helicase/nuclease 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dna2provided by RGD
Official Full Name: DNA replication helicase/nuclease 2provided by RGD
Primary source: RGD:1306791
See related: AllianceGenome:RGD:1306791
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dna2l
Summary: Predicted to enable ATP hydrolysis activity; catalytic activity, acting on DNA; and nucleic acid binding activity. Predicted to be involved in DNA metabolic process and DNA replication checkpoint signaling. Predicted to be located in mitochondrial inner membrane; mitochondrial nucleoid; and nucleoplasm. Predicted to be part of gamma DNA polymerase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Seckel syndrome 8; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6; isolated growth hormone deficiency type IA; and mitochondrial myopathy. Orthologous to human DNA2 (DNA replication helicase/nuclease 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 20q11

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (25660339..25689285, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (25661652..25690598, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH128448 (e-PCR)
- UniSTS:211756

AU049833 (e-PCR)
- UniSTS:146279

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 5'-3' DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables 5'-3' DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 5'-flap endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-flap endonuclease activity	IEA Inferred from Electronic Annotation more info
enables 5'-flap endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
NOT enables DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables forked DNA-dependent helicase activity	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables single-stranded 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables site-specific endodeoxyribonuclease activity, specific for altered base	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA double-strand break processing	IEA Inferred from Electronic Annotation more info
involved_in DNA double-strand break processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA replication checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in DNA replication checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA replication, Okazaki fragment processing	IEA Inferred from Electronic Annotation more info
involved_in DNA replication, Okazaki fragment processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA replication, removal of RNA primer	IEA Inferred from Electronic Annotation more info
involved_in base-excision repair	IEA Inferred from Electronic Annotation more info
involved_in base-excision repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial DNA repair	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial DNA replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in replication fork reversal	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of gamma DNA polymerase complex	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: DNA replication ATP-dependent helicase/nuclease DNA2

Names: DNA replication ATP-dependent helicase-like homolog; DNA replication helicase 2 homolog; DNA2 DNA replication helicase 2-like; DNA2-like helicase

NP_001376551.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001389622.1 → NP_001376551.1 DNA replication ATP-dependent helicase/nuclease DNA2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

D3ZG52

UniProtKB/TrEMBL

A0A8I5ZZI9

Conserved Domains (3) summary

cd18041
Location:625 → 828

DEXXQc_DNA2; DEXXQ-box helicase domain of DNA2

pfam13087
Location:805 → 1017

AAA_12; AAA domain

cd22318
Location:127 → 366

DNA2_N-like; Nuclease domain of the nuclease/helicase DNA2 and related nucleases