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Mdga1 MAM domain containing glycosylphosphatidylinositol anchor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309659, updated on 27-Nov-2024

Summary

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Official Symbol
Mdga1provided by RGD
Official Full Name
MAM domain containing glycosylphosphatidylinositol anchor 1provided by RGD
Primary source
RGD:1307031
See related
EnsemblRapid:ENSRNOG00000000536 AllianceGenome:RGD:1307031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Involved in central nervous system development and regulation of synapse organization. Located in plasma membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. Orthologous to human MDGA1 (MAM domain containing glycosylphosphatidylinositol anchor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 21.3), Brain (RPKM 12.2) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mdga1 in Genome Data Viewer
Location:
20p12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (7901856..7965834, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (7900327..7964309, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (8515142..8574632, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S20 like 5 Neighboring gene ribosomal protein S15, pseudogene 19 Neighboring gene uncharacterized LOC120098975 Neighboring gene uncharacterized LOC120098917 Neighboring gene uncharacterized LOC120098952

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior. Toledo A, et al. Elife, 2022 May 9. PMID 35532105, Free PMC Article
  2. Radial migration of superficial layer cortical neurons controlled by novel Ig cell adhesion molecule MDGA1. Takeuchi A, et al. J Neurosci, 2006 Apr 26. PMID 16641224, Free PMC Article
  3. Characterization of MDGA1, a novel human glycosylphosphatidylinositol-anchored protein localized in lipid rafts. Díaz-López A, et al. Exp Cell Res, 2005 Jul 1. PMID 15922729
  4. Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn. Li HL, et al. Neurochem Res, 2024 Feb. PMID 37955815
  5. Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges. Gangwar SP, et al. Neuron, 2017 Jun 21. PMID 28641112, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn.
    Title: Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn.
  2. MDGA binding and suppression of synaptogenic activity was selective for neuroligin-2 and not neuroligin-1 excitatory synapse organizer.
    Title: Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse development.
  3. MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development.
    Title: MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in brain development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cerebral cortex radially oriented cell migration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cerebral cortex radially oriented cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in inhibitory synapse assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inhibitory synapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in presynapse assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within presynapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of presynapse assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of presynapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synapse maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic membrane adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic membrane adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in spinal cord association neuron differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
is_active_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MAM domain-containing glycosylphosphatidylinositol anchor protein 1
Names
ig6M

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414944.1 → NP_001401873.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/Swiss-Prot
    P85171
    Related
    ENSRNOP00000111019.1, ENSRNOT00000124884.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    7901856..7965834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601653.3 → XP_017457142.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A140TAF4
    Related
    ENSRNOP00000099314.1, ENSRNOT00000140475.1

  2. XM_039098719.2 → XP_038954647.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A140TAF4
    Related
    ENSRNOP00000040424.7, ENSRNOT00000048845.7
    Conserved Domains (6) summary
    smart00408
    Location:254 → 315
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:450 → 535
    IG_like; Immunoglobulin like
    pfam00629
    Location:754 → 890
    MAM; MAM domain, meprin/A5/mu
    pfam13927
    Location:132 → 217
    Ig_3; Immunoglobulin domain
    cd00096
    Location:240 → 242
    Ig; Ig strand A [structural motif]
    cl11960
    Location:54 → 115
    Ig; Immunoglobulin domain

  3. XM_039098720.2 → XP_038954648.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform X3

    Conserved Domains (5) summary
    smart00408
    Location:254 → 315
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:450 → 535
    IG_like; Immunoglobulin like
    pfam13927
    Location:132 → 217
    Ig_3; Immunoglobulin domain
    cd00096
    Location:240 → 242
    Ig; Ig strand A [structural motif]
    cl11960
    Location:54 → 115
    Ig; Immunoglobulin domain

  4. XM_039098721.2 → XP_038954649.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform X4

    Conserved Domains (5) summary
    smart00408
    Location:254 → 315
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:450 → 535
    IG_like; Immunoglobulin like
    pfam13927
    Location:132 → 217
    Ig_3; Immunoglobulin domain
    cd00096
    Location:240 → 242
    Ig; Ig strand A [structural motif]
    cl11960
    Location:54 → 115
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107618.1: Suppressed sequence

    Description
    NM_001107618.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P85171.1 GenPept UniProtKB/Swiss-Prot:P85171

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