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Cmtr1 cap methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309656, updated on 27-Nov-2024

Summary

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Official Symbol
Cmtr1provided by RGD
Official Full Name
cap methyltransferase 1provided by RGD
Primary source
RGD:1307801
See related
EnsemblRapid:ENSRNOG00000000532 AllianceGenome:RGD:1307801
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MTr1; Ftsjd2; LRRG00129; RGD1307801
Summary
Predicted to enable mRNA (nucleoside-2'-O-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human CMTR1 (cap methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 208.9), Adrenal (RPKM 195.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cmtr1 in Genome Data Viewer
Location:
20p12
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (7724286..7784787)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (7722729..7782579)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (8324968..8385174)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 22B Neighboring gene ring finger protein 8 Neighboring gene coiled-coil domain containing 167 Neighboring gene ribosomal protein S15, pseudogene 19 Neighboring gene ribosomal protein S20 like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase. Bélanger F, et al. J Biol Chem, 2010 Oct 22. PMID 20713356, Free PMC Article
  2. 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. Werner M, et al. Nucleic Acids Res, 2011 Jun. PMID 21310715, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA (nucleoside-2'-O-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA (nucleoside-2'-O-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA (nucleoside-2'-O-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables mRNA (nucleoside-2'-O-)-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 7-methylguanosine mRNA capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 7-methylguanosine mRNA capping IEA
Inferred from Electronic Annotation
more info
  
involved_in 7-methylguanosine mRNA capping ISO
Inferred from Sequence Orthology
more info
  
involved_in 7-methylguanosine mRNA capping ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Names
FtsJ methyltransferase domain containing 2
S-adenosyl-L-methionine-dependent methyltransferase FTSJD2
cap1 2'O-ribose methyltransferase 1
ftsJ methyltransferase domain-containing protein 2
NP_001014053.1
XP_038954644.1
XP_038954645.1
XP_038954646.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014031.1 → NP_001014053.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

    See identical proteins and their annotated locations for NP_001014053.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085799
    UniProtKB/Swiss-Prot
    Q5U2Z5
    UniProtKB/TrEMBL
    A0A8I6AHL4, A6JJV9
    Related
    ENSRNOP00000080385.1, ENSRNOT00000101461.2
    Conserved Domains (3) summary
    pfam01585
    Location:86 → 128
    G-patch; G-patch domain
    pfam01728
    Location:231 → 447
    FtsJ; FtsJ-like methyltransferase
    cl12015
    Location:622 → 739
    Adenylation_DNA_ligase_like; Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    7724286..7784787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098717.2 → XP_038954645.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GIF5
    Related
    ENSRNOP00000081353.2, ENSRNOT00000111387.2
    Conserved Domains (3) summary
    pfam01585
    Location:86 → 128
    G-patch; G-patch domain
    pfam01728
    Location:231 → 447
    FtsJ; FtsJ-like methyltransferase
    cl12015
    Location:622 → 739
    Adenylation_DNA_ligase_like; Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases

  2. XM_039098718.2 → XP_038954646.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X3

    Conserved Domains (2) summary
    pfam01585
    Location:86 → 128
    G-patch; G-patch domain
    cl17173
    Location:231 → 368
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_039098716.2 → XP_038954644.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5U2Z5
    UniProtKB/TrEMBL
    A0A8I6AHL4, A6JJV9
    Conserved Domains (3) summary
    pfam01585
    Location:86 → 128
    G-patch; G-patch domain
    pfam01728
    Location:231 → 447
    FtsJ; FtsJ-like methyltransferase
    cl12015
    Location:622 → 739
    Adenylation_DNA_ligase_like; Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2Z5.1 GenPept UniProtKB/Swiss-Prot:Q5U2Z5

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