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Ppil1 peptidylprolyl isomerase like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309651, updated on 27-Nov-2024

Summary

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Official Symbol
Ppil1provided by RGD
Official Full Name
peptidylprolyl isomerase like 1provided by RGD
Primary source
RGD:1309119
See related
EnsemblRapid:ENSRNOG00000000523 AllianceGenome:RGD:1309119
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable disordered domain specific binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in embryonic brain development; gene expression; and protein peptidyl-prolyl isomerization. Predicted to be located in nucleus. Predicted to be part of U2-type catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 14. Orthologous to human PPIL1 (peptidylprolyl isomerase like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 338.4), Spleen (RPKM 190.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppil1 in Genome Data Viewer
Location:
20p12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (7303919..7323962, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (7302292..7322349, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (6515638..6864571, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483865 Neighboring gene copine 5 Neighboring gene uncharacterized LOC102547155 Neighboring gene transfer RNA threonine (anticodon AGU) 18 Neighboring gene similar to human chromosome 6 open reading frame 89 Neighboring gene uncharacterized LOC120098949 Neighboring gene peptidase inhibitor 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A large intrinsically disordered region in SKIP and its disorder-order transition induced by PPIL1 binding revealed by NMR. Wang X, et al. J Biol Chem, 2010 Feb 12. PMID 20007319, Free PMC Article
  2. Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP. Xu C, et al. J Biol Chem, 2006 Jun 9. PMID 16595688
  3. Spliceosomal immunophilins. Mesa A, et al. FEBS Lett, 2008 Jul 9. PMID 18544344, Free PMC Article
  4. Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. Davis TL, et al. PLoS Biol, 2010 Jul 27. PMID 20676357, Free PMC Article
  5. Splicing and beyond: the many faces of the Prp19 complex. Chanarat S, et al. Biochim Biophys Acta, 2013 Oct. PMID 23742842

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC116359

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in embryonic brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein peptidyl-prolyl isomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase-like 1
Names
peptidylprolyl isomerase (cyclophilin)-like 1
NP_001029360.1
XP_063135217.1
XP_063135218.1
XP_063135219.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034188.1 → NP_001029360.1  peptidyl-prolyl cis-trans isomerase-like 1

    See identical proteins and their annotated locations for NP_001029360.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099188
    UniProtKB/TrEMBL
    F7FJ93, Q4KLI4
    Related
    ENSRNOP00000076232.1, ENSRNOT00000093253.3
    Conserved Domains (1) summary
    cd01922
    Location:15 → 161
    cyclophilin_SpCYP2_like; cyclophilin 2-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to Schizosaccharomyces pombe cyp-2. These proteins bind their respective SNW chromatin binding protein in autologous systems, in a CsA independent manner indicating ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    7303919..7323962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279148.1 → XP_063135218.1  peptidyl-prolyl cis-trans isomerase-like 1 isoform X1

    UniProtKB/TrEMBL
    F7FJ93, Q4KLI4

  2. XM_063279147.1 → XP_063135217.1  peptidyl-prolyl cis-trans isomerase-like 1 isoform X1

    UniProtKB/TrEMBL
    F7FJ93, Q4KLI4

  3. XM_063279149.1 → XP_063135219.1  peptidyl-prolyl cis-trans isomerase-like 1 isoform X1

    UniProtKB/TrEMBL
    F7FJ93, Q4KLI4
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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