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Sh3pxd2a SH3 and PX domains 2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 309460, updated on 4-Jan-2025

Summary

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Official Symbol
Sh3pxd2aprovided by RGD
Official Full Name
SH3 and PX domains 2Aprovided by RGD
Primary source
RGD:1311185
See related
EnsemblRapid:ENSRNOG00000089802 AllianceGenome:RGD:1311185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sh3md1
Summary
Predicted to enable several functions, including phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in osteoclast fusion and superoxide anion generation. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in podosome. Predicted to be active in cytoplasm. Orthologous to human SH3PXD2A (SH3 and PX domains 2A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 125.1), Heart (RPKM 112.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sh3pxd2a in Genome Data Viewer
Location:
1q54
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (256094991..256301120, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (246153660..246359806, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (267039654..267245868, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene calcium homeostasis modulator 3 Neighboring gene neuralized E3 ubiquitin protein ligase 1 Neighboring gene uncharacterized LOC102552122 Neighboring gene transfer RNA proline (anticodon AGG) 27 Neighboring gene uncharacterized LOC134485242 Neighboring gene STN1 subunit of CST complex

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo. Blouw B, et al. Eur J Cell Biol, 2008 Sep. PMID 18417249, Free PMC Article
  2. Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation. Diaz B, et al. Sci Signal, 2009 Sep 15. PMID 19755709, Free PMC Article
  3. Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion. Oikawa T, et al. J Cell Biol, 2012 May 14. PMID 22584907, Free PMC Article
  4. Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation. Gianni D, et al. Eur J Cell Biol, 2011 Feb-Mar. PMID 20609497, Free PMC Article
  5. The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. Abram CL, et al. J Biol Chem, 2003 May 9. PMID 12615925

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-5-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables superoxide-generating NADPH oxidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoclast fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in podosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SH3 and PX domain-containing protein 2A
Names
SH3 multiple domains 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107606.3 → NP_001101076.2  SH3 and PX domain-containing protein 2A isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6G2U9, D3ZMW5
    Related
    ENSRNOP00000102896.1, ENSRNOT00000149640.1

  2. NM_001415946.2 → NP_001402875.1  SH3 and PX domain-containing protein 2A isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6AD93, D3ZMW5
    Related
    ENSRNOP00000109997.1, ENSRNOT00000139157.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    256094991..256301120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231514.5 → XP_006231576.1  SH3 and PX domain-containing protein 2A isoform X1

    UniProtKB/TrEMBL
    A0A8I6AP29, D3ZMW5
    Related
    ENSRNOP00000102627.1, ENSRNOT00000123173.1
    Conserved Domains (6) summary
    cd06888
    Location:6 → 124
    PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
    cd12019
    Location:810 → 861
    SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12020
    Location:1039 → 1095
    SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12074
    Location:170 → 222
    SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12077
    Location:241 → 294
    SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12079
    Location:422 → 475
    SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains

  2. XM_039080588.2 → XP_038936516.1  SH3 and PX domain-containing protein 2A isoform X2

    UniProtKB/TrEMBL
    A0A0G2JX92, A6JHQ5
    Conserved Domains (6) summary
    cd12019
    Location:787 → 838
    SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12020
    Location:1016 → 1072
    SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12074
    Location:119 → 171
    SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12077
    Location:218 → 271
    SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12079
    Location:399 → 452
    SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cl02563
    Location:1 → 73
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
Nucleotide Protein Strain
Heading Accession and Version

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