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Wbp1l WW domain binding protein 1-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 309456, updated on 27-Nov-2024

Summary

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Official Symbol
Wbp1lprovided by RGD
Official Full Name
WW domain binding protein 1-likeprovided by RGD
Primary source
RGD:1305793
See related
EnsemblRapid:ENSRNOG00000020020 AllianceGenome:RGD:1305793
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Opal1; RGD1305793
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in CXCL12-activated CXCR4 signaling pathway. Predicted to act upstream of or within hemopoiesis and positive regulation of protein ubiquitination. Predicted to be located in membrane. Orthologous to human WBP1L (WW domain binding protein 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 220.1), Adrenal (RPKM 199.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wbp1l in Genome Data Viewer
Location:
1q54
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (255413701..255470026)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245472292..245528627)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (266358728..266415296)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ARF like GTPase 3 Neighboring gene transfer RNA histidin (anticodon AUG) Neighboring gene sideroflexin 2 Neighboring gene uncharacterized LOC120100047 Neighboring gene cytochrome P450, family 17, subfamily a, polypeptide 1 Neighboring gene uncharacterized LOC134484084 Neighboring gene BLOC-1 related complex subunit 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. [Role of long non-coding RNA BC088414 in hypoxic-ischemic injury of neural cells]. Zhao FY, et al. Zhongguo Dang Dai Er Ke Za Zhi, 2015 Dec. PMID 26695678
  2. Microarray Profiling and Co-Expression Network Analysis of LncRNAs and mRNAs in Neonatal Rats Following Hypoxic-ischemic Brain Damage. Zhao F, et al. Sci Rep, 2015 Sep 9. PMID 26349411, Free PMC Article
  3. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC188498

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CXCL12-activated CXCR4 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CXCL12-activated CXCR4 signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within CXCL12-activated CXCR4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WW domain binding protein 1-like
Names
outcome predictor in acute leukemia 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127484.1 → NP_001120956.1  WW domain binding protein 1-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_001120956.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZU54, A6JHN2, B2RYF0, F7F8B3
    Related
    ENSRNOP00000027118.6, ENSRNOT00000027118.8
    Conserved Domains (1) summary
    pfam11669
    Location:43 → 144
    WBP-1; WW domain-binding protein 1

  2. NM_001313908.1 → NP_001300837.1  WW domain binding protein 1-like isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' exon, contains an alternate 5' terminal exon, uses an alternate splice site in an internal exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZU54, A0A8I6B248
    Related
    ENSRNOP00000095179.1, ENSRNOT00000110025.2
    Conserved Domains (1) summary
    pfam11669
    Location:43 → 121
    WBP-1; WW domain-binding protein 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    255413701..255470026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080554.1 → XP_038936482.1  WW domain binding protein 1-like isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZU54, A0A8I6B248
    Conserved Domains (1) summary
    pfam11669
    Location:43 → 121
    WBP-1; WW domain-binding protein 1

  2. XM_006231508.5 → XP_006231570.1  WW domain binding protein 1-like isoform X1

    See identical proteins and their annotated locations for XP_006231570.1

    UniProtKB/Swiss-Prot
    P0C1G7
    UniProtKB/TrEMBL
    A0A8I5ZU54
    Related
    ENSRNOP00000082448.1, ENSRNOT00000116056.2
    Conserved Domains (1) summary
    pfam11669
    Location:22 → 123
    WBP-1; WW domain-binding protein 1

  3. XM_017589294.2 → XP_017444783.1  WW domain binding protein 1-like isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZU54, A0A8I6B248
    Conserved Domains (1) summary
    pfam11669
    Location:43 → 121
    WBP-1; WW domain-binding protein 1

  4. XM_039080560.2 → XP_038936488.1  WW domain binding protein 1-like isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZU54
    Conserved Domains (1) summary
    pfam11669
    Location:3 → 82
    WBP-1; WW domain-binding protein 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C1G7.1 GenPept UniProtKB/Swiss-Prot:P0C1G7

Gene LinkOut

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