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Mrpl43 mitochondrial ribosomal protein L43 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309440, updated on 27-Nov-2024

Summary

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Official Symbol
Mrpl43provided by RGD
Official Full Name
mitochondrial ribosomal protein L43provided by RGD
Primary source
RGD:1307593
See related
EnsemblRapid:ENSRNOG00000014890 AllianceGenome:RGD:1307593
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL43 (mitochondrial ribosomal protein L43). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 158.9), Liver (RPKM 153.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mrpl43 in Genome Data Viewer
Location:
1q54
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (253816009..253817441, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (243866848..243868285, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (264755537..264756404, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene SMC5-SMC6 complex localization factor 2 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene semaphorin 4G Neighboring gene twinkle mtDNA helicase Neighboring gene leucine zipper tumor suppressor 2 Neighboring gene PDZ domain containing 7 Neighboring gene sideroflexin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
  2. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein mL43
Names
39S ribosomal protein L43, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399464.2 → NP_001386393.1  large ribosomal subunit protein mL43

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JHH2, D3ZXF8
    Related
    ENSRNOP00000020020.5, ENSRNOT00000020020.7
    Conserved Domains (1) summary
    smart00916
    Location:38 → 107
    L51_S25_CI-B8; Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    253816009..253817441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107598.1: Suppressed sequence

    Description
    NM_001107598.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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