Uhrf2 ubiquitin like with PHD and ring finger domains 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uhrf2provided by RGD
Official Full Name: ubiquitin like with PHD and ring finger domains 2provided by RGD
Primary source: RGD:1309990
See related: EnsemblRapid:ENSRNOG00000011308 AllianceGenome:RGD:1309990
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; histone binding activity; and ubiquitin-like protein transferase activity. Predicted to be involved in several processes, including negative regulation of gene expression via chromosomal CpG island methylation; protein autoubiquitination; and regulation of cell cycle. Predicted to be located in nucleoplasm and pericentric heterochromatin. Orthologous to human UHRF2 (ubiquitin like with PHD and ring finger domains 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 340.5), Thymus (RPKM 243.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q52

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (237224050..237291406)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (227814639..227877907)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (248228496..248291984)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142949 (e-PCR)
- UniSTS:232196

BI275765 (e-PCR)
- UniSTS:249648

RH135184 (e-PCR)
- UniSTS:218461

BF413085 (e-PCR)
- UniSTS:248496

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables SUMO transferase activity	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression via chromosomal CpG island methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in heterochromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in pericentric heterochromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase UHRF2

Names: ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase; ubiquitin-like, containing PHD and RING finger domains 2

NP_001101055.1

EC 2.3.2.27

XP_038935936.1

EC 2.3.2.27

XP_038935940.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107585.1 → NP_001101055.1 E3 ubiquitin-protein ligase UHRF2

See identical proteins and their annotated locations for NP_001101055.1

Status: PROVISIONAL

Source sequence(s)

CH473953

UniProtKB/TrEMBL

A6I0X9, D3ZK36

Related

ENSRNOP00000015406.4, ENSRNOT00000015406.7

Conserved Domains (6) summary

cd01797
Location:1 → 76

NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF

smart00213
Location:3 → 74

UBQ; Ubiquitin homologues

cd00162
Location:733 → 776

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd15617
Location:347 → 393

PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)

pfam02182
Location:447 → 615

SAD_SRA; SAD/SRA domain

pfam12148
Location:126 → 313

TTD; Tandem tudor domain within UHRF1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

237224050..237291406

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080012.2 → XP_038935940.1 E3 ubiquitin-protein ligase UHRF2 isoform X2

Conserved Domains (4) summary

cd15617
Location:347 → 393

PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)

cd17123
Location:1 → 74

Ubl_UHRF2; ubiquitin-like (Ubl) domain found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)

pfam02182
Location:447 → 538

SAD_SRA; SAD/SRA domain

pfam12148
Location:126 → 313

TTD; Tandem tudor domain within UHRF1
XM_039080008.2 → XP_038935936.1 E3 ubiquitin-protein ligase UHRF2 isoform X1

Conserved Domains (5) summary

COG5222
Location:478 → 579

COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

cd15617
Location:123 → 169

PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)

cd16613
Location:508 → 553

RING-HC_UHRF; RING finger, HC subclass, found in ubiquitin-like PHD and RING finger domain-containing proteins, UHRF1 and UHRF2, and similar proteins

pfam02182
Location:223 → 391

SAD_SRA; SAD/SRA domain

pfam12148
Location:1 → 89

TTD; Tandem tudor domain within UHRF1