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Ptgdr2 prostaglandin D2 receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309212, updated on 4-Jan-2025

Summary

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Official Symbol
Ptgdr2provided by RGD
Official Full Name
prostaglandin D2 receptor 2provided by RGD
Primary source
RGD:1311986
See related
EnsemblRapid:ENSRNOG00000090389 AllianceGenome:RGD:1311986
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpr44
Summary
Predicted to enable neuropeptide binding activity and prostaglandin receptor activity. Predicted to be involved in calcium-mediated signaling; chemotaxis; and neuropeptide signaling pathway. Predicted to act upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of male germ cell proliferation; and positive regulation of G protein-coupled receptor signaling pathway. Predicted to be active in neuron projection and plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR2 (prostaglandin D2 receptor 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 83.4), Lung (RPKM 29.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ptgdr2 in Genome Data Viewer
Location:
1q43
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (217010183..217015044)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207585088..207590275)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226976455..226995641)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 19 Neighboring gene zona pellucida glycoprotein 1 Neighboring gene coiled-coil domain containing 86 Neighboring gene membrane spanning 4-domains A10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Role of prostaglandin D2 /CRTH2 pathway on asthma exacerbation induced by Aspergillus fumigatus. Liu H, et al. Immunology, 2014 May. PMID 24329550, Free PMC Article
  2. COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons. Kanda H, et al. Glia, 2013 Jun. PMID 23505121
  3. Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis. Stearns BA, et al. Bioorg Med Chem Lett, 2009 Aug 15. PMID 19608418
  4. Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways. Tirouvanziam R, et al. Proc Natl Acad Sci U S A, 2008 Mar 18. PMID 18334635, Free PMC Article
  5. Role of prostaglandin D2 receptor CRTH2 in sustained eosinophil accumulation in the airways of mice with chronic asthma. Kagawa S, et al. Int Arch Allergy Immunol, 2011. PMID 21646789

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRTh2 mediates most prostaglandin D2 pro-inflammatory effects and long receptor residence time of antagonist LAS191859 translates into long-lasting in vivo efficacy.
    Title: Pharmacological characterization of CRTh2 antagonist LAS191859: Long receptor residence time translates into long-lasting in vivo efficacy.
  2. Production of prostaglandin D2 followed by eosinophil recruitment into the airways via a CRTH2 receptor are the major pathogenic factors responsible for the A. fumigatus-induced enhancement of airway inflammation and responsiveness.
    Title: Role of prostaglandin D2 /CRTH2 pathway on asthma exacerbation induced by Aspergillus fumigatus.
  3. We believe that PGD2 signaling via DP2 signaling pathway from microglia to neurons is one of the triggering factors for mechanical allodynia in this neuropathic pain model.
    Title: COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prostaglandin D receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prostaglandin D receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables prostaglandin D receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables prostaglandin F receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables prostaglandin J receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of male germ cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prostaglandin D2 receptor 2
Names
G protein-coupled receptor 44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012070.1 → NP_001012070.1  prostaglandin D2 receptor 2

    See identical proteins and their annotated locations for NP_001012070.1

    Status: PROVISIONAL

    Source sequence(s)
    AY228550
    UniProtKB/Swiss-Prot
    Q6XKD3
    Conserved Domains (2) summary
    cd14964
    Location:33 → 59
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:32 → 314
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    217010183..217015044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264453.1 → XP_063120523.1  prostaglandin D2 receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6XKD3
    Related
    ENSRNOP00000104794.1, ENSRNOT00000153762.1

  2. XM_039079849.2 → XP_038935777.1  prostaglandin D2 receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6XKD3
    Conserved Domains (2) summary
    cd14964
    Location:33 → 59
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:32 → 314
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_063264455.1 → XP_063120525.1  prostaglandin D2 receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6XKD3
    Related
    ENSRNOP00000066082.1, ENSRNOT00000054808.6

  4. XM_039079846.2 → XP_038935774.1  prostaglandin D2 receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6XKD3
    Conserved Domains (2) summary
    cd14964
    Location:33 → 59
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:32 → 314
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. XM_039079847.2 → XP_038935775.1  prostaglandin D2 receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6XKD3
    Related
    ENSRNOP00000102756.1, ENSRNOT00000128375.1
    Conserved Domains (2) summary
    cd14964
    Location:33 → 59
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:32 → 314
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6XKD3.1 GenPept UniProtKB/Swiss-Prot:Q6XKD3

Gene LinkOut

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