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Atl3 atlastin GTPase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309187, updated on 2-Nov-2024

Summary

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Official Symbol
Atl3provided by RGD
Official Full Name
atlastin GTPase 3provided by RGD
Primary source
RGD:1309871
See related
EnsemblRapid:ENSRNOG00000021203 AllianceGenome:RGD:1309871
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309871
Summary
Predicted to enable GTP binding activity; GTPase activity; and identical protein binding activity. Predicted to be involved in several processes, including Golgi organization; positive regulation of endoplasmic reticulum tubular network organization; and protein homooligomerization. Predicted to be located in endoplasmic reticulum tubular network membrane. Human ortholog(s) of this gene implicated in hereditary sensory neuropathy type 1F. Orthologous to human ATL3 (atlastin GTPase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 394.9), Adrenal (RPKM 355.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Atl3 in Genome Data Viewer
Location:
1q43
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (214110127..214151098)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204680958..204727360)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222746023..222788439)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483963 Neighboring gene spindlin interactor and repressor of chromatin binding Neighboring gene zinc finger translocation associated Neighboring gene reticulon 3 Neighboring gene uncharacterized LOC102551693 Neighboring gene cell division cycle associated 5 like 1 Neighboring gene Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cellular localization, oligomerization, and membrane association of the hereditary spastic paraplegia 3A (SPG3A) protein atlastin. Zhu PP, et al. J Biol Chem, 2003 Dec 5. PMID 14506257
  2. Atlastin GTPases are required for Golgi apparatus and ER morphogenesis. Rismanchi N, et al. Hum Mol Genet, 2008 Jun 1. PMID 18270207, Free PMC Article
  3. Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum. Chen S, et al. Proc Natl Acad Sci U S A, 2015 Jan 13. PMID 25548161, Free PMC Article
  4. Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation. Chang J, et al. Proc Natl Acad Sci U S A, 2013 Sep 10. PMID 23969831, Free PMC Article
  5. Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network. Wang S, et al. Elife, 2016 Sep 13. PMID 27619977, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IEA
Inferred from Electronic Annotation
more info
  
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to type II interferon IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum organization IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum organization ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endoplasmic reticulum tubular network organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endoplasmic reticulum tubular network organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endoplasmic reticulum tubular network organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein homooligomerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum tubular network ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum tubular network ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum tubular network membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum tubular network membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum tubular network membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
atlastin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044241.1 → NP_001037706.1  atlastin-3

    See identical proteins and their annotated locations for NP_001037706.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ450893
    UniProtKB/TrEMBL
    A0A0G2JSS9, A0A8I6AEN1
    Related
    ENSRNOP00000092838.1, ENSRNOT00000106102.2
    Conserved Domains (1) summary
    cl21455
    Location:32 → 300
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    214110127..214151098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589257.3 → XP_017444746.1  atlastin-3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JSS9
    Related
    ENSRNOP00000095818.2, ENSRNOT00000096486.2

  2. XM_006230812.5 → XP_006230874.1  atlastin-3 isoform X1

    UniProtKB/Swiss-Prot
    Q0ZHH6
    Conserved Domains (1) summary
    cl21455
    Location:37 → 305
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0ZHH6.2 GenPept UniProtKB/Swiss-Prot:Q0ZHH6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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