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Lto1 LTO1 maturation factor of ABCE1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309136, updated on 2-Nov-2024

Summary

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Official Symbol
Lto1provided by RGD
Official Full Name
LTO1 maturation factor of ABCE1provided by RGD
Primary source
RGD:1304637
See related
EnsemblRapid:ENSRNOG00000020903 AllianceGenome:RGD:1304637
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Oraov1
Summary
Predicted to be involved in gene expression; ribosomal large subunit biogenesis; and telomere maintenance. Orthologous to human LTO1 (LTO1 maturation factor of ABCE1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 45.3), Lung (RPKM 43.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lto1 in Genome Data Viewer
Location:
1q42
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (209502900..209510237)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (200074247..200080951)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (218075995..218082700)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485204 Neighboring gene fibroblast growth factor 19 Neighboring gene brain cytoplasmic RNA 1 Neighboring gene ribosomal protein S10, pseudogene 18 Neighboring gene cyclin D1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome. Zhai C, et al. Oncogene, 2014 Jan 23. PMID 23318452
  2. The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion. Paul VD, et al. Elife, 2015 Jul 16. PMID 26182403, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein maturation by [4Fe-4S] cluster transfer ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal large subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein LTO1 homolog
Names
LTO1, ABCE1 maturation factor
oral cancer overexpressed 1
oral cancer-overexpressed protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107565.1 → NP_001101035.1  protein LTO1 homolog

    See identical proteins and their annotated locations for NP_001101035.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A0A8I6A2Q3, A6HYI1, A6HYI3
    Conserved Domains (1) summary
    pfam09811
    Location:107 → 145
    Yae1_N; Essential protein Yae1, N terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    209502900..209510237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264152.1 → XP_063120222.1  protein LTO1 homolog isoform X1

  2. XM_063264161.1 → XP_063120231.1  protein LTO1 homolog isoform X4

  3. XM_017589240.3 → XP_017444729.2  protein LTO1 homolog isoform X2

    Related
    ENSRNOP00000085622.2, ENSRNOT00000114678.2

  4. XM_017589242.3 → XP_017444731.2  protein LTO1 homolog isoform X5

  5. XM_017589241.3 → XP_017444730.2  protein LTO1 homolog isoform X3

  6. XM_039079182.2 → XP_038935110.2  protein LTO1 homolog isoform X6

  7. XM_063264171.1 → XP_063120241.1  protein LTO1 homolog isoform X7

Nucleotide Protein Strain
Heading Accession and Version

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