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Btbd10 BTB domain containing 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308890, updated on 27-Nov-2024

Summary

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Official Symbol
Btbd10provided by RGD
Official Full Name
BTB domain containing 10provided by RGD
Primary source
RGD:1306301
See related
EnsemblRapid:ENSRNOG00000014341 AllianceGenome:RGD:1306301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306301
Summary
Predicted to be involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human BTBD10 (BTB domain containing 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 79.4), Brain (RPKM 67.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Btbd10 in Genome Data Viewer
Location:
1q33
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (176865817..176923663, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (167431311..167489320, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (178138562..178196551, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099909 Neighboring gene basic helix-loop-helix ARNT like 1 Neighboring gene uncharacterized LOC134484822 Neighboring gene RNA, U6 small nuclear 26 Neighboring gene parathyroid hormone Neighboring gene enolase 1, pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Early changes in GMRP1 after intracerebral hemorrhage: involvement in brain damage and cell apoptosis. Wang X, et al. Acta Neurochir Suppl, 2013. PMID 23564125
  2. Involvement of GMRP1, a novel mediator of Akt pathway, in brain damage after intracerebral hemorrhage. Zheng M, et al. Int J Clin Exp Pathol, 2013. PMID 23330007, Free PMC Article
  3. Glucose metabolism-related protein 1 (GMRP1) regulates pancreatic beta cell proliferation and apoptosis via activation of Akt signalling pathway in rats and mice. Wang X, et al. Diabetologia, 2011 Apr. PMID 21267538
  4. A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. Nawa M, et al. Cell Signal, 2008 Mar. PMID 18160256
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC105916

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein 10
Names
BTB (POZ) domain containing 10
K+ channel tetramerization protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014022.2 → NP_001014044.1  BTB/POZ domain-containing protein 10 isoform b

    See identical proteins and their annotated locations for NP_001014044.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6AQE4, Q5EAP0
    Conserved Domains (1) summary
    cd18385
    Location:117 → 226
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

  2. NM_001399401.1 → NP_001386330.1  BTB/POZ domain-containing protein 10 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    F7EZ61
    Related
    ENSRNOP00000060287.2, ENSRNOT00000067170.4
    Conserved Domains (1) summary
    cd18385
    Location:165 → 274
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

  3. NM_001399402.1 → NP_001386331.1  BTB/POZ domain-containing protein 10 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    F7EZ61
    Conserved Domains (1) summary
    cd18385
    Location:165 → 274
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

  4. NM_001399403.1 → NP_001386332.1  BTB/POZ domain-containing protein 10 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    Q5EAP0
    Conserved Domains (1) summary
    cd18385
    Location:117 → 226
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

  5. NM_001399404.1 → NP_001386333.1  BTB/POZ domain-containing protein 10 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    Q5EAP0
    Related
    ENSRNOP00000096128.1, ENSRNOT00000099504.2
    Conserved Domains (1) summary
    cd18385
    Location:117 → 226
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    176865817..176923663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039113416.2 → XP_038969344.1  BTB/POZ domain-containing protein 10 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AQE4, Q5EAP0
    Conserved Domains (1) summary
    cd18385
    Location:117 → 226
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

  2. XM_017589192.2 → XP_017444681.1  BTB/POZ domain-containing protein 10 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AQE4, F7EZ61
    Conserved Domains (1) summary
    cd18385
    Location:165 → 274
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

  3. XM_039113392.2 → XP_038969320.1  BTB/POZ domain-containing protein 10 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JZA0, A0A8I6AQE4
    Related
    ENSRNOP00000070965.1, ENSRNOT00000081767.3
    Conserved Domains (1) summary
    cd18385
    Location:154 → 263
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

  4. XM_039113386.2 → XP_038969314.1  BTB/POZ domain-containing protein 10 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AQE4, F7EZ61
    Conserved Domains (1) summary
    cd18385
    Location:165 → 274
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

  5. XM_006230038.5 → XP_006230100.1  BTB/POZ domain-containing protein 10 isoform X2

    See identical proteins and their annotated locations for XP_006230100.1

    UniProtKB/TrEMBL
    A0A8I6AQE4, F7EZ61
    Conserved Domains (1) summary
    cd18385
    Location:165 → 274
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

  6. XM_063262859.1 → XP_063118929.1  BTB/POZ domain-containing protein 10 isoform X2

    UniProtKB/TrEMBL
    F7EZ61

  7. XM_006230033.5 → XP_006230095.1  BTB/POZ domain-containing protein 10 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A2B2, A0A8I6AQE4
    Related
    ENSRNOP00000086484.1, ENSRNOT00000096757.2
    Conserved Domains (1) summary
    pfam16017
    Location:209 → 438
    BTB_3; BTB/POZ domain

  8. XM_039113428.2 → XP_038969356.1  BTB/POZ domain-containing protein 10 isoform X5

    Conserved Domains (1) summary
    cd18385
    Location:173 → 282
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)
Nucleotide Protein Strain
Heading Accession and Version

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