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Dnajb13 DnaJ heat shock protein family (Hsp40) member B13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308857, updated on 4-Jan-2025

Summary

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Official Symbol
Dnajb13provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member B13provided by RGD
Primary source
RGD:1359131
See related
EnsemblRapid:ENSRNOG00000017975 AllianceGenome:RGD:1359131
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tsarg1
Summary
Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to be involved in axonemal central apparatus assembly and chaperone cofactor-dependent protein refolding. Predicted to be located in axoneme; sperm flagellum; and sperm head-tail coupling apparatus. Predicted to be part of radial spoke. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 34. Orthologous to human DNAJB13 (DnaJ heat shock protein family (Hsp40) member B13). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 123.5), Spleen (RPKM 32.6) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dnajb13 in Genome Data Viewer
Location:
1q32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (164260716..164275172, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (154848586..154863042, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165515718..165530163, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncoupling protein 3 Neighboring gene uncoupling protein 2 Neighboring gene uncharacterized LOC103691200 Neighboring gene uncharacterized LOC120099893 Neighboring gene cytochrome c oxidase assembly factor 4 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning of a novel rat gene Tsarg1, a member of the DnaJ/HSP40 protein family. Yang HM, et al. DNA Seq, 2005 Jun. PMID 16147871
  2. Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility. El Khouri E, et al. Am J Hum Genet, 2016 Aug 4. PMID 27486783, Free PMC Article
  3. DNAJB13, a type II HSP40 family member, localizes to the spermatids and spermatozoa during mouse spermatogenesis. Li W, et al. BMC Dev Biol, 2014 Sep 19. PMID 25233908, Free PMC Article
  4. Essential role for SUN5 in anchoring sperm head to the tail. Shang Y, et al. Elife, 2017 Sep 25. PMID 28945193, Free PMC Article
  5. A heat-shock protein 40, DNAJB13, is an axoneme-associated component in mouse spermatozoa. Guan J, et al. Mol Reprod Dev, 2008 Sep. PMID 18247331

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tsarg1 is specifically expressed in rat testis, which probably inhibits rat testis spermatogenic cell apoptosis
    Title: Molecular cloning of a novel rat gene Tsarg1, a member of the DnaJ/HSP40 protein family.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axonemal central apparatus assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
part_of radial spoke ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  
located_in sperm head-tail coupling apparatus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily B member 13
Names
DnaJ (Hsp40) homolog, subfamily B, member 13
DnaJ (Hsp40) related, subfamily B, member 13
testis spermatogenesis apoptosis-related protein 1
testis spermatogenesis apoptosis-related protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005885.2 → NP_001005885.1  dnaJ homolog subfamily B member 13

    See identical proteins and their annotated locations for NP_001005885.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098002
    UniProtKB/TrEMBL
    A6I6P4, B3LEP3, Q5YKV6
    Related
    ENSRNOP00000024256.5, ENSRNOT00000024256.7
    Conserved Domains (3) summary
    cd10747
    Location:138 → 302
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:1 → 312
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:4 → 65
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    164260716..164275172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229766.3 → XP_006229828.1  dnaJ homolog subfamily B member 13 isoform X1

    UniProtKB/TrEMBL
    A6I6P4
    Conserved Domains (3) summary
    cd10747
    Location:137 → 301
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:1 → 311
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:4 → 64
    DnaJ; DnaJ domain

  2. XM_063262811.1 → XP_063118881.1  dnaJ homolog subfamily B member 13 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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