Efl1 elongation factor like GTPase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Efl1provided by RGD
Official Full Name: elongation factor like GTPase 1provided by RGD
Primary source: RGD:1306521
See related: EnsemblRapid:ENSRNOG00000032723 AllianceGenome:RGD:1306521
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Eftud1
Summary: Predicted to enable GTPase activity and ribosome binding activity. Predicted to be involved in GTP metabolic process and cytosolic ribosome assembly. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Shwachman-Diamond syndrome. Orthologous to human EFL1 (elongation factor like GTPase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 97.7), Kidney (RPKM 79.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (146047734..146172719)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (136638527..136763518)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (144601425..144740634)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH131275 (e-PCR)
- UniSTS:214558

BE113889 (e-PCR)
- UniSTS:246833

RH135444 (e-PCR)
- UniSTS:218721

BE099025 (e-PCR)
- UniSTS:245606

D1Wox7 (e-PCR)
- UniSTS:117940

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GTP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cytosolic ribosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytosolic ribosome assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: elongation factor-like GTPase 1

Names: elongation factor Tu GTP binding domain containing 1; elongation factor Tu GTP-binding domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107534.1 → NP_001101004.1 elongation factor-like GTPase 1

See identical proteins and their annotated locations for NP_001101004.1

Status: PROVISIONAL

Source sequence(s)

CH473980

UniProtKB/TrEMBL

A6JCK4, D3ZXJ5

Related

ENSRNOP00000049519.4, ENSRNOT00000047408.7

Conserved Domains (6) summary

cd01885
Location:20 → 253

EF2; Elongation Factor 2 (EF2) in archaea and eukarya

cd01681
Location:687 → 993

aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...

cd04096
Location:990 → 1068

eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...

PTZ00416
Location:1 → 1110

PTZ00416; elongation factor 2; Provisional

cd16268
Location:505 → 600

EF2_II; Domain II of Elongation Factor 2

cd16261
Location:616 → 687

EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)