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Man2a2 mannosidase, alpha, class 2A, member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308757, updated on 2-Nov-2024

Summary

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Official Symbol
Man2a2provided by RGD
Official Full Name
mannosidase, alpha, class 2A, member 2provided by RGD
Primary source
RGD:1310238
See related
EnsemblRapid:ENSRNOG00000012055 AllianceGenome:RGD:1310238
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable alpha-mannosidase activity and hydrolase activity, hydrolyzing N-glycosyl compounds. Predicted to be involved in N-glycan processing. Predicted to be active in Golgi membrane. Orthologous to human MAN2A2 (mannosidase alpha class 2A member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 153.8), Testes (RPKM 151.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Man2a2 in Genome Data Viewer
Location:
1q31
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143712157..143736624, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134304714..134327611, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142141695..142164561, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene shisa like 3 Neighboring gene HD domain containing 3 Neighboring gene ribosomal protein L35A like 7 Neighboring gene FES proto-oncogene, tyrosine kinase Neighboring gene uncharacterized LOC102553801 Neighboring gene furin (paired basic amino acid cleaving enzyme)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice. Akama TO, et al. Proc Natl Acad Sci U S A, 2006 Jun 13. PMID 16754854, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing N-glycosyl compounds ISO
Inferred from Sequence Orthology
more info
  
enables mannosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
alpha-mannosidase 2x
Names
mannosidase 2, alpha 2
NP_001100997.1
XP_008757749.1
XP_008757751.1
XP_008757752.1
XP_017444654.1
XP_063118711.1
XP_063118712.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107527.1 → NP_001100997.1  alpha-mannosidase 2x

    See identical proteins and their annotated locations for NP_001100997.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473980
    UniProtKB/TrEMBL
    A0A0G2JWG1, A6JCB0
    Related
    ENSRNOP00000016281.9, ENSRNOT00000016281.9
    Conserved Domains (4) summary
    PLN02701
    Location:140 → 1163
    PLN02701; alpha-mannosidase
    smart00872
    Location:503 → 588
    Alpha-mann_mid; Alpha mannosidase, middle domain
    pfam07748
    Location:761 → 1159
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
    cl15692
    Location:165 → 508
    CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    143712157..143736624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262641.1 → XP_063118711.1  alpha-mannosidase 2x isoform X2

  2. XM_008759529.4 → XP_008757751.1  alpha-mannosidase 2x isoform X1

    See identical proteins and their annotated locations for XP_008757751.1

    UniProtKB/TrEMBL
    A0A0G2JWG1
    Conserved Domains (4) summary
    PLN02701
    Location:140 → 1174
    PLN02701; alpha-mannosidase
    smart00872
    Location:503 → 588
    Alpha-mann_mid; Alpha mannosidase, middle domain
    pfam07748
    Location:761 → 1170
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
    cl15692
    Location:165 → 508
    CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily

  3. XM_008759530.4 → XP_008757752.1  alpha-mannosidase 2x isoform X2

    UniProtKB/TrEMBL
    A0A0G2JWG1
    Conserved Domains (4) summary
    PLN02701
    Location:140 → 1149
    PLN02701; alpha-mannosidase
    smart00872
    Location:503 → 588
    Alpha-mann_mid; Alpha mannosidase, middle domain
    pfam07748
    Location:761 → 1145
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
    cl15692
    Location:165 → 508
    CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily

  4. XM_008759527.4 → XP_008757749.1  alpha-mannosidase 2x isoform X1

    See identical proteins and their annotated locations for XP_008757749.1

    UniProtKB/TrEMBL
    A0A0G2JWG1
    Related
    ENSRNOP00000069866.3, ENSRNOT00000078982.3
    Conserved Domains (4) summary
    PLN02701
    Location:140 → 1174
    PLN02701; alpha-mannosidase
    smart00872
    Location:503 → 588
    Alpha-mann_mid; Alpha mannosidase, middle domain
    pfam07748
    Location:761 → 1170
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
    cl15692
    Location:165 → 508
    CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily

  5. XM_017589165.3 → XP_017444654.1  alpha-mannosidase 2x isoform X1

    UniProtKB/TrEMBL
    A0A0G2JWG1
    Conserved Domains (4) summary
    PLN02701
    Location:140 → 1174
    PLN02701; alpha-mannosidase
    smart00872
    Location:503 → 588
    Alpha-mann_mid; Alpha mannosidase, middle domain
    pfam07748
    Location:761 → 1170
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
    cl15692
    Location:165 → 508
    CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily

  6. XM_063262642.1 → XP_063118712.1  alpha-mannosidase 2x isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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