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Tars3 threonyl-tRNA synthetase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308701, updated on 27-Nov-2024

Summary

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Symbol
Tars3provided by RGD
Full Name
threonyl-tRNA synthetase 3provided by RGD
Primary source
RGD:1311308
See related
EnsemblRapid:ENSRNOG00000024460 AllianceGenome:RGD:1311308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tarsl2; RGD1311308
Summary
Predicted to enable threonine-tRNA ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be located in cytoplasm and nucleus. Orthologous to human TARS3 (threonyl-tRNA synthetase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 171.6), Muscle (RPKM 152.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tars3 in Genome Data Viewer
Location:
1q22
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (128623678..128675978)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (119213189..119265492)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (126523169..126559493)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546680 Neighboring gene uncharacterized LOC120099841 Neighboring gene TM2 domain containing 3 Neighboring gene uncharacterized LOC108349586 Neighboring gene uncharacterized LOC120099842

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities. Chen Y, et al. Nucleic Acids Res, 2018 Apr 20. PMID 29579307, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables threonine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables threonine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in threonyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in threonyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
threonine--tRNA ligase 2, cytoplasmic
Names
probable threonine--tRNA ligase 2, cytoplasmic
probable threonyl-tRNA synthetase 2, cytoplasmic
threonyl-tRNA synthetase-like 2
NP_001388464.1
XP_063118538.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401535.1 → NP_001388464.1  threonine--tRNA ligase 2, cytoplasmic

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6AAW1, A6JBN1
    Related
    ENSRNOP00000090461.1, ENSRNOT00000110192.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    128623678..128675978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262468.1 → XP_063118538.1  threonine--tRNA ligase 2, cytoplasmic isoform X1

RNA

  1. XR_005505558.2 RNA Sequence

  2. XR_005505557.2 RNA Sequence

    Related
    ENSRNOT00000051000.6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001014020.1: Suppressed sequence

    Description
    NM_001014020.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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