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Rhpn2 rhophilin, Rho GTPase binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308516, updated on 27-Nov-2024

Summary

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Official Symbol
Rhpn2provided by RGD
Official Full Name
rhophilin, Rho GTPase binding protein 2provided by RGD
Primary source
RGD:1308366
See related
EnsemblRapid:ENSRNOG00000011885 AllianceGenome:RGD:1308366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in negative regulation of stress fiber assembly. Predicted to act upstream of or within glomerular filtration. Predicted to be located in plasma membrane. Orthologous to several human genes including RHPN2 (rhophilin Rho GTPase binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 57.2), Liver (RPKM 43.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rhpn2 in Genome Data Viewer
Location:
1q21
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (97128054..97188803)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (87991143..88051895)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (91596344..91657395)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene G patch domain containing 1 Neighboring gene small nuclear ribonucleoprotein polypeptide G like 1 Neighboring gene FA core complex associated protein 24 Neighboring gene centrosomal protein 89 Neighboring gene solute carrier family 7 member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within glomerular filtration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rhophilin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107505.2 → NP_001100975.1  rhophilin-2

    See identical proteins and their annotated locations for NP_001100975.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JAA8, D4A8N7
    Related
    ENSRNOP00000016148.5, ENSRNOT00000016148.7
    Conserved Domains (3) summary
    cd11634
    Location:27 → 108
    HR1_Rhophilin-2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rhophilin-2
    cd00992
    Location:520 → 591
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14649
    Location:112 → 496
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    97128054..97188803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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