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B3gnt8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308440, updated on 9-Dec-2024

Summary

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Official Symbol
B3gnt8provided by RGD
Official Full Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8provided by RGD
Primary source
RGD:1305374
See related
EnsemblRapid:ENSRNOG00000068024 AllianceGenome:RGD:1305374
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
B3galt7
Summary
Predicted to enable protein N-acetylglucosaminyltransferase activity. Predicted to be involved in poly-N-acetyllactosamine biosynthetic process and protein O-linked glycosylation. Predicted to be active in Golgi membrane. Orthologous to human B3GNT8 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Adrenal (RPKM 15.8), Heart (RPKM 14.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See B3gnt8 in Genome Data Viewer
Location:
1q21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (90263387..90266292)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (81135602..81138501)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (82419264..82422852)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549342 Neighboring gene CEA cell adhesion molecule 1 Neighboring gene glutamate-rich 4 Neighboring gene distal membrane arm assembly component 2 Neighboring gene branched chain keto acid dehydrogenase E1 subunit alpha Neighboring gene exosome component 5 Neighboring gene transmembrane protein 91

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer. Ishida H, et al. FEBS Lett, 2005 Jan 3. PMID 15620693
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in poly-N-acetyllactosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in poly-N-acetyllactosamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
Names
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107492.1 → NP_001100962.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

    See identical proteins and their annotated locations for NP_001100962.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473979
    UniProtKB/TrEMBL
    A6J972, D3ZE36
    Conserved Domains (1) summary
    cl21608
    Location:154 → 341
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    90263387..90266292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228434.5 → XP_006228496.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 isoform X1

    See identical proteins and their annotated locations for XP_006228496.1

    UniProtKB/TrEMBL
    A6J972, D3ZE36
    Related
    ENSRNOP00000083186.1, ENSRNOT00000104230.2
    Conserved Domains (1) summary
    cl21608
    Location:154 → 341
    Galactosyl_T; Galactosyltransferase

  2. XM_063261364.1 → XP_063117434.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 isoform X1

    UniProtKB/TrEMBL
    A6J972, D3ZE36
    Related
    ENSRNOP00000109412.1, ENSRNOT00000156740.1
Nucleotide Protein Strain
Heading Accession and Version

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