Tmc4 transmembrane channel-like 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Tmc4provided by RGD
Full Name: transmembrane channel-like 4provided by RGD
Primary source: RGD:1304811
See related: EnsemblRapid:ENSRNOG00000059741 AllianceGenome:RGD:1304811
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmc4b
Summary: Predicted to enable mechanosensitive monoatomic ion channel activity and voltage-gated chloride channel activity. Predicted to be involved in sensory perception of salty taste. Predicted to be located in plasma membrane. Orthologous to human TMC4 (transmembrane channel like 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Lung (RPKM 115.5), Kidney (RPKM 88.9) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (74455135..74467043)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (65539777..65551683)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (64114687..64126576)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

RH132676 (e-PCR)
- UniSTS:215959

RH132704 (e-PCR)
- UniSTS:215987

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mechanosensitive monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated chloride channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of salty taste	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of salty taste	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: voltage-gated chloride channel TMC4

Names: transmembrane channel-like 4B; transmembrane channel-like gene family 4; transmembrane channel-like protein 4; transmembrane channel-like protein 4-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.