Rab11fip2 RAB11 family interacting protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rab11fip2provided by RGD
Full Name: RAB11 family interacting protein 2provided by RGD
Primary source: RGD:1308538
See related: EnsemblRapid:ENSRNOG00000009523 AllianceGenome:RGD:1308538
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308538; Rab11-FIP2
Summary: Predicted to enable protein homodimerization activity and protein kinase binding activity. Involved in positive regulation of protein localization to plasma membrane. Predicted to be located in nucleoplasm. Predicted to be active in endosome and phagocytic cup. Orthologous to human RAB11FIP2 (RAB11 family interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 154.4), Adrenal (RPKM 145.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (268908825..269080691, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (258950535..259094555, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (281065346..281101163, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors propose a retention-release mechanism, where Rab11fip2 acts as a gate that restricts the trafficking of AMPA receptors, until long-term potentiation induction triggers their release and allows synaptic delivery.
Title: A retention-release mechanism based on RAB11FIP2 for AMPA receptor synaptic delivery during long-term potentiation.
This study provided the first evidence indicating that a signaling receptor regulates the activity and dynamics of Rab11-positive endosomes to induce a cellular response.
Title: BDNF regulates Rab11-mediated recycling endosome dynamics to induce dendritic branching.
Data demonstrate that AMPH leads to an increase of NET in endosomes of single boutons and varicosities in a Rab11-dependent manner.
Title: Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in TRAM-dependent toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulated exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulated exocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in phagocytic cup	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic cup	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rab11 family-interacting protein 2

Names: RAB11 family interacting protein 2 (class I)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107447.2 → NP_001100917.2 rab11 family-interacting protein 2

See identical proteins and their annotated locations for NP_001100917.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AF99, A0A8I6ASH5, A6JI91

Related

ENSRNOP00000012734.7, ENSRNOT00000012734.9

Conserved Domains (2) summary

cd08682
Location:15 → 141

C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I

pfam09457
Location:452 → 499

RBD-FIP; FIP domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

268908825..269080691 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063288295.1 → XP_063144365.1 rab11 family-interacting protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I6A6W2
XM_039110359.2 → XP_038966287.1 rab11 family-interacting protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I6A6W2, A0A8I6ASH5

Conserved Domains (2) summary

cd08682
Location:15 → 141

C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I

pfam09457
Location:452 → 499

RBD-FIP; FIP domain
XM_063288292.1 → XP_063144362.1 rab11 family-interacting protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I6A6W2

Related

ENSRNOP00000087232.1, ENSRNOT00000081218.3