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Spire2 spire-type actin nucleation factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307925, updated on 27-Nov-2024

Summary

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Official Symbol
Spire2provided by RGD
Official Full Name
spire-type actin nucleation factor 2provided by RGD
Primary source
RGD:1305837
See related
EnsemblRapid:ENSRNOG00000016920 AllianceGenome:RGD:1305837
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including cytoskeleton organization; cytoskeleton-dependent cytokinesis; and positive regulation of double-strand break repair. Predicted to be located in cleavage furrow. Predicted to be active in cell cortex and cytoplasmic vesicle membrane. Orthologous to human SPIRE2 (spire type actin nucleation factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 39.0), Testes (RPKM 26.4) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Spire2 in Genome Data Viewer
Location:
19q12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (68281878..68320427)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (51373368..51411920)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (56136904..56175500)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein (C2H2 type) 276 Neighboring gene small nucleolar RNA SNORD43 Neighboring gene FA complementation group A Neighboring gene transcription factor 25 Neighboring gene melanocortin 1 receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected]. Belin BJ, et al. Elife, 2015 Aug 19. PMID 26287480, Free PMC Article
  2. An actin-dependent mechanism for long-range vesicle transport. Schuh M. Nat Cell Biol, 2011 Oct 9. PMID 21983562, Free PMC Article
  3. Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division. Pfender S, et al. Curr Biol, 2011 Jun 7. PMID 21620703, Free PMC Article
  4. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament network formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in cleavage furrow formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cleavage furrow formation ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of meiotic spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of meiotic spindle localization ISO
Inferred from Sequence Orthology
more info
  
involved_in formin-nucleated actin cable assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular transport ISO
Inferred from Sequence Orthology
more info
  
involved_in polar body extrusion after meiotic divisions IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in polar body extrusion after meiotic divisions ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein spire homolog 2
Names
spire homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127538.2 → NP_001121010.2  protein spire homolog 2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6IZX8, B2RYF2, G3V870
    Related
    ENSRNOP00000022823.4, ENSRNOT00000022823.8
    Conserved Domains (6) summary
    cl28890
    Location:566 → 680
    FYVE_like_SF; FYVE domain like superfamily
    pfam16474
    Location:26 → 212
    KIND; Kinase non-catalytic C-lobe domain
    cd22065
    Location:237 → 268
    WH2_Spire_1-2_r1; first tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2
    cd22079
    Location:279 → 308
    WH2_Spire2_r2; second tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 2
    cd22081
    Location:343 → 364
    WH2_Spire2_r4; fourth tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 2
    cd22186
    Location:311 → 333
    WH2_Spire1-2_r3; third tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    68281878..68320427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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