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Mtss2 MTSS I-BAR domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307845, updated on 4-Jan-2025

Summary

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Official Symbol
Mtss2provided by RGD
Official Full Name
MTSS I-BAR domain containing 2provided by RGD
Primary source
RGD:1309731
See related
EnsemblRapid:ENSRNOG00000017500 AllianceGenome:RGD:1309731
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Abba-1; Mtss1l; RGD1309731
Summary
Predicted to enable several functions, including GTPase activator activity; actin monomer binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including activation of GTPase activity; cell projection assembly; and cellular response to platelet-derived growth factor stimulus. Predicted to act upstream of or within lamellipodium organization. Predicted to be located in cortical actin cytoskeleton; lamellipodium; and ruffle membrane. Predicted to be active in actin cytoskeleton and cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in intellectual developmental disorder with ocular anomalies and distinctive facial features. Orthologous to human MTSS2 (MTSS I-BAR domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 138.2), Brain (RPKM 97.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtss2 in Genome Data Viewer
Location:
19q12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55602180..55623955)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (38692793..38714575)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (40904779..40925660, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene VAC14 component of PIKFYVE complex Neighboring gene transfer RNA glycine (anticodon GCC) 9 Neighboring gene uncharacterized LOC134483369 Neighboring gene uncharacterized LOC134483366 Neighboring gene interleukin 34 Neighboring gene ribosomal protein L29 like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Abba promotes PDGF-mediated membrane ruffling through activation of the small GTPase Rac1. Zheng D, et al. Biochem Biophys Res Commun, 2010 Oct 29. PMID 20875796, Free PMC Article
  2. ABBA regulates plasma-membrane and actin dynamics to promote radial glia extension. Saarikangas J, et al. J Cell Sci, 2008 May 1. PMID 18413296
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin monomer binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to platelet-derived growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lamellipodium organization ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma membrane organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein MTSS 2
Names
MTSS1-like protein
MTSS1L, I-BAR domain containing
actin-bundling protein with BAIAP2 homology
metastasis suppressor 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191558.1 → NP_001178487.1  protein MTSS 2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A8I5ZL76
    Conserved Domains (1) summary
    cd07643
    Location:6 → 236
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    55602180..55623955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097762.2 → XP_038953690.1  protein MTSS 2 isoform X1

    UniProtKB/TrEMBL
    D4A3S6
    Conserved Domains (2) summary
    cd07643
    Location:6 → 236
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cd22060
    Location:735 → 765
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

  2. XM_063278057.1 → XP_063134127.1  protein MTSS 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZL76

  3. XM_039097765.2 → XP_038953693.1  protein MTSS 2 isoform X2

    UniProtKB/TrEMBL
    D4A3S6
    Related
    ENSRNOP00000023645.6, ENSRNOT00000023645.7
    Conserved Domains (2) summary
    cd07643
    Location:6 → 236
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cd22060
    Location:716 → 746
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

  4. XM_063278058.1 → XP_063134128.1  protein MTSS 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AHN6
Nucleotide Protein Strain
Heading Accession and Version

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