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Hmgxb4 HMG-box containing 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307667, updated on 27-Nov-2024

Summary

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Official Symbol
Hmgxb4provided by RGD
Official Full Name
HMG-box containing 4provided by RGD
Primary source
RGD:1305783
See related
EnsemblRapid:ENSRNOG00000013878 AllianceGenome:RGD:1305783
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hmg2l1; Hmgb2l1
Summary
Predicted to enable identical protein binding activity. Predicted to be part of NURF complex. Orthologous to human HMGXB4 (HMG-box containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 48.6), Lung (RPKM 38.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hmgxb4 in Genome Data Viewer
Location:
19p11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (13370559..13409306)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (13364741..13403563)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (14352644..14390499)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103694287 Neighboring gene ribosomal protein S2, pseudogene 41 Neighboring gene uncharacterized LOC102556139 Neighboring gene target of myb1 membrane trafficking protein Neighboring gene uncharacterized LOC134483111 Neighboring gene heme oxygenase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Repression of smooth muscle differentiation by a novel high mobility group box-containing protein, HMG2L1. Zhou J, et al. J Biol Chem, 2010 Jul 23. PMID 20511232, Free PMC Article
  2. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Vermeulen M, et al. Cell, 2010 Sep 17. PMID 20850016

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the first evidence of this novel HMG2L1 molecule playing an important role in attenuating smooth muscle differentiation
    Title: Repression of smooth muscle differentiation by a novel high mobility group box-containing protein, HMG2L1.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NURF complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
HMG domain-containing protein 4
Names
HMG box domain containing 4
high mobility group box 2-like 1
high-mobility group protein 2-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415029.1 → NP_001401958.1  HMG domain-containing protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019

  2. NM_001415030.1 → NP_001401959.1  HMG domain-containing protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    Related
    ENSRNOP00000103951.1, ENSRNOT00000122073.1

  3. NM_001415031.1 → NP_001401960.1  HMG domain-containing protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019

  4. NM_001415032.1 → NP_001401961.1  HMG domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    D4A2N0
    Related
    ENSRNOP00000061759.2, ENSRNOT00000067519.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    13370559..13409306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278001.1 → XP_063134071.1  HMG domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y143
    Related
    ENSRNOP00000098894.1, ENSRNOT00000144216.1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107412.1: Suppressed sequence

    Description
    NM_001107412.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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