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Kifc3 kinesin family member C3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307644, updated on 27-Nov-2024

Summary

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Official Symbol
Kifc3provided by RGD
Official Full Name
kinesin family member C3provided by RGD
Primary source
RGD:1307693
See related
EnsemblRapid:ENSRNOG00000014087 AllianceGenome:RGD:1307693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
KRP4
Summary
Predicted to enable identical protein binding activity and microtubule binding activity. Predicted to be involved in epithelial cell-cell adhesion; microtubule-based process; and zonula adherens maintenance. Predicted to act upstream of or within Golgi organization. Predicted to be located in several cellular components, including Golgi apparatus; centrosome; and zonula adherens. Predicted to be part of kinesin complex. Predicted to be active in microtubule cytoskeleton. Orthologous to human KIFC3 (kinesin family member C3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 88.0), Adrenal (RPKM 44.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kifc3 in Genome Data Viewer
Location:
19p13
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9831159..9926405)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9825114..9920371)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10305405..10339186)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene sperm microtubule inner protein 8 Neighboring gene cyclic nucleotide gated channel subunit beta 1 Neighboring gene RNA, U2 small nuclear 69, pseudogene Neighboring gene uncharacterized LOC134483686 Neighboring gene katanin regulatory subunit B1 Neighboring gene dynein regulatory complex subunit 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Role of KIFC3 motor protein in Golgi positioning and integration. Xu Y, et al. J Cell Biol, 2002 Jul 22. PMID 12135985, Free PMC Article
  2. Kinesin-related proteins in the mammalian testes: candidate motors for meiosis and morphogenesis. Sperry AO, et al. Mol Biol Cell, 1996 Feb. PMID 8688559, Free PMC Article
  3. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Meng W, et al. Cell, 2008 Nov 28. PMID 19041755
  4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC156699

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule-based process ISO
Inferred from Sequence Orthology
more info
  
involved_in zonula adherens maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
part_of kinesin complex ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in zonula adherens ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinesin-like protein KIFC3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001103352.1 → NP_001096822.1  kinesin-like protein KIFC3 isoform 2

    See identical proteins and their annotated locations for NP_001096822.1

    Status: PROVISIONAL

    Source sequence(s)
    BC128748
    UniProtKB/TrEMBL
    A0A8I6A4I8, A1A5P4
    Conserved Domains (3) summary
    cd01366
    Location:370 → 697
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:378 → 695
    Kinesin; Kinesin motor domain
    cl12013
    Location:108 → 233
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_001401191.1 → NP_001388120.1  kinesin-like protein KIFC3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    Related
    ENSRNOP00000080196.2, ENSRNOT00000104498.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    9831159..9926405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097698.1 → XP_038953626.1  kinesin-like protein KIFC3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ADV7
    Conserved Domains (2) summary
    COG1196
    Location:231 → 548
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:598 → 925
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  2. XM_017601265.2 → XP_017456754.2  kinesin-like protein KIFC3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ADV7
    Conserved Domains (2) summary
    COG1196
    Location:230 → 547
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:597 → 924
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  3. XM_063277982.1 → XP_063134052.1  kinesin-like protein KIFC3 isoform X4

  4. XM_039097699.1 → XP_038953627.1  kinesin-like protein KIFC3 isoform X6

    UniProtKB/TrEMBL
    F7EXA8
    Conserved Domains (2) summary
    TIGR02168
    Location:179 → 488
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:491 → 818
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  5. XM_017601270.2 → XP_017456759.2  kinesin-like protein KIFC3 isoform X7

    UniProtKB/TrEMBL
    F7EXA8
    Related
    ENSRNOP00000094247.2, ENSRNOT00000107028.2
    Conserved Domains (2) summary
    TIGR02168
    Location:179 → 488
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:491 → 818
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  6. XM_017601266.3 → XP_017456755.2  kinesin-like protein KIFC3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ADV7
    Conserved Domains (2) summary
    COG1196
    Location:231 → 548
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:598 → 925
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  7. XM_017601269.3 → XP_017456758.2  kinesin-like protein KIFC3 isoform X5

    UniProtKB/TrEMBL
    A0A8I6ADV7
    Related
    ENSRNOP00000092397.1, ENSRNOT00000095742.2
    Conserved Domains (2) summary
    COG1196
    Location:231 → 548
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:598 → 925
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  8. XM_039097701.2 → XP_038953629.1  kinesin-like protein KIFC3 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AKJ1
    Conserved Domains (3) summary
    TIGR02168
    Location:93 → 402
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:405 → 732
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam08317
    Location:26 → 150
    Spc7; Spc7 kinetochore protein

  9. XM_039097700.2 → XP_038953628.1  kinesin-like protein KIFC3 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AKJ1
    Conserved Domains (3) summary
    TIGR02168
    Location:93 → 402
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:405 → 732
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam08317
    Location:26 → 150
    Spc7; Spc7 kinetochore protein

  10. XM_063277983.1 → XP_063134053.1  kinesin-like protein KIFC3 isoform X9

  11. XM_008772292.4 → XP_008770514.2  kinesin-like protein KIFC3 isoform X9

    UniProtKB/TrEMBL
    A0A8I6AKJ1
    Conserved Domains (2) summary
    TIGR02168
    Location:58 → 367
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:370 → 697
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  12. XM_008772293.3 → XP_008770515.2  kinesin-like protein KIFC3 isoform X10

    UniProtKB/TrEMBL
    A0A8I6AKJ1
    Related
    ENSRNOP00000085654.2, ENSRNOT00000093890.2
    Conserved Domains (2) summary
    TIGR02168
    Location:49 → 358
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:361 → 688
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  13. XM_063277984.1 → XP_063134054.1  kinesin-like protein KIFC3 isoform X11

RNA

  1. XR_005496646.2 RNA Sequence

  2. XR_005496647.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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