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Dtna dystrobrevin, alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 307548, updated on 27-Nov-2024

Summary

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Official Symbol
Dtnaprovided by RGD
Official Full Name
dystrobrevin, alphaprovided by RGD
Primary source
RGD:1561985
See related
EnsemblRapid:ENSRNOG00000016671 AllianceGenome:RGD:1561985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dtna-ps1; RGD1561985
Summary
Enables PDZ domain binding activity and phosphatase binding activity. Predicted to be involved in synaptic signaling. Located in axon and sarcolemma. Is extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in cardiomyopathy and left ventricular noncompaction. Orthologous to human DTNA (dystrobrevin alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 123.4), Brain (RPKM 87.8) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dtna in Genome Data Viewer
Location:
18p12
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (14862801..15218993)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (14687193..14944232)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (14544725..14671514)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene nucleolar protein 4 Neighboring gene cytochrome b5 type A, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120098123 Neighboring gene uncharacterized LOC134482916 Neighboring gene uncharacterized LOC120098122 Neighboring gene ribosomal protein L10, pseudogene 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. WW and EF hand domains of dystrophin-family proteins mediate dystroglycan binding. Chung W, et al. Mol Cell Biol Res Commun, 1999 Sep-Dec. PMID 10662592
  2. Immunolocalization of dystrobrevin in the astrocytic endfeet and endothelial cells in the rat cerebellum. Ueda H, et al. Neurosci Lett, 2000 Apr 7. PMID 10739890
  3. Dystrobrevin localization in photoreceptor axon terminals and at blood-ocular barrier sites. Ueda H, et al. Invest Ophthalmol Vis Sci, 2000 Nov. PMID 11053293
  4. Characterization of the intermolecular associations of the dystrophin-associated glycoprotein complex in retinal Müller glial cells. Claudepierre T, et al. J Cell Sci, 2000 Oct. PMID 10984432
  5. Expression of the skeletal muscle dystrophin-dystroglycan complex and syntrophin-nitric oxide synthase complex is severely affected in the type 2 diabetic Goto-Kakizaki rat. Mulvey C, et al. Eur J Cell Biol, 2005 Nov. PMID 16323284

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphatase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in synaptic signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dystrobrevin alpha
Names
dystrobrevin alpha, pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427105.1 → NP_001414034.1  dystrobrevin alpha

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    Related
    ENSRNOP00000098322.2, ENSRNOT00000120690.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    14862801..15218993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277418.1 → XP_063133488.1  dystrobrevin alpha isoform X1

  2. XM_063277429.1 → XP_063133499.1  dystrobrevin alpha isoform X7

  3. XM_063277438.1 → XP_063133508.1  dystrobrevin alpha isoform X12

  4. XM_063277432.1 → XP_063133502.1  dystrobrevin alpha isoform X9

    UniProtKB/TrEMBL
    A0A8I6AQU5

  5. XM_063277420.1 → XP_063133490.1  dystrobrevin alpha isoform X1

  6. XM_063277428.1 → XP_063133498.1  dystrobrevin alpha isoform X7

  7. XM_063277439.1 → XP_063133509.1  dystrobrevin alpha isoform X12

  8. XM_063277433.1 → XP_063133503.1  dystrobrevin alpha isoform X9

    UniProtKB/TrEMBL
    A0A8I6AQU5

  9. XM_063277436.1 → XP_063133506.1  dystrobrevin alpha isoform X10

  10. XM_063277441.1 → XP_063133511.1  dystrobrevin alpha isoform X15

  11. XM_039097220.2 → XP_038953148.1  dystrobrevin alpha isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZQM2, A6J2I4
    Related
    ENSRNOP00000080605.1, ENSRNOT00000112648.3
    Conserved Domains (3) summary
    COG0419
    Location:422 → 557
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  12. XM_063277425.1 → XP_063133495.1  dystrobrevin alpha isoform X2

  13. XM_039097225.2 → XP_038953153.1  dystrobrevin alpha isoform X7

    Conserved Domains (3) summary
    COG0419
    Location:365 → 500
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  14. XM_063277435.1 → XP_063133505.1  dystrobrevin alpha isoform X10

  15. XM_063277421.1 → XP_063133491.1  dystrobrevin alpha isoform X1

  16. XM_063277424.1 → XP_063133494.1  dystrobrevin alpha isoform X1

  17. XM_063277434.1 → XP_063133504.1  dystrobrevin alpha isoform X9

    UniProtKB/TrEMBL
    A0A8I6AQU5

  18. XM_039097218.2 → XP_038953146.1  dystrobrevin alpha isoform X1

    Conserved Domains (3) summary
    COG0419
    Location:422 → 557
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  19. XM_039097226.2 → XP_038953154.1  dystrobrevin alpha isoform X9

    UniProtKB/TrEMBL
    A0A8I6AQU5
    Conserved Domains (4) summary
    COG0419
    Location:365 → 494
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl09111
    Location:438 → 576
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

  20. XM_063277427.1 → XP_063133497.1  dystrobrevin alpha isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZQM2

  21. XM_039097235.2 → XP_038953163.1  dystrobrevin alpha isoform X6

    UniProtKB/TrEMBL
    A6J2I4
    Conserved Domains (4) summary
    COG1340
    Location:466 → 547
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    pfam10186
    Location:417 → 591
    Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

  22. XM_063277426.1 → XP_063133496.1  dystrobrevin alpha isoform X3

    Related
    ENSRNOP00000096468.2, ENSRNOT00000097179.2

  23. XM_063277431.1 → XP_063133501.1  dystrobrevin alpha isoform X8

  24. XM_039097234.2 → XP_038953162.1  dystrobrevin alpha isoform X5

    UniProtKB/TrEMBL
    A6J2I4
    Related
    ENSRNOP00000103129.1, ENSRNOT00000128772.1
    Conserved Domains (4) summary
    COG0419
    Location:422 → 551
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:465 → 655
    MS_channel; Mechanosensitive ion channel

  25. XM_039097231.2 → XP_038953159.1  dystrobrevin alpha isoform X13

    UniProtKB/TrEMBL
    A6J2I5
    Conserved Domains (4) summary
    COG1340
    Location:409 → 490
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:407 → 597
    MS_channel; Mechanosensitive ion channel

  26. XM_039097227.2 → XP_038953155.1  dystrobrevin alpha isoform X11

    UniProtKB/TrEMBL
    A6J2I5
    Related
    ENSRNOP00000104545.1, ENSRNOT00000127932.1
    Conserved Domains (3) summary
    COG0419
    Location:365 → 500
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  27. XM_017601081.3 → XP_017456570.2  dystrobrevin alpha isoform X14

    UniProtKB/TrEMBL
    A0A8I5ZKV1
    Related
    ENSRNOP00000042067.6, ENSRNOT00000045224.9
    Conserved Domains (3) summary
    COG0419
    Location:365 → 500
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  28. XM_017601083.3 → XP_017456572.2  dystrobrevin alpha isoform X16

    UniProtKB/TrEMBL
    A0A8I6APF7
    Related
    ENSRNOP00000095584.1, ENSRNOT00000114052.2
    Conserved Domains (2) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  29. XM_063277437.1 → XP_063133507.1  dystrobrevin alpha isoform X12

  30. XM_063277423.1 → XP_063133493.1  dystrobrevin alpha isoform X1

  31. XM_063277419.1 → XP_063133489.1  dystrobrevin alpha isoform X1

  32. XM_063277430.1 → XP_063133500.1  dystrobrevin alpha isoform X7

  33. XM_063277440.1 → XP_063133510.1  dystrobrevin alpha isoform X14

  34. XM_063277442.1 → XP_063133512.1  dystrobrevin alpha isoform X16

    UniProtKB/TrEMBL
    A0A8I6APF7
Nucleotide Protein Strain
Heading Accession and Version

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