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Hars2 histidyl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 307491, updated on 4-Jan-2025

Summary

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Official Symbol
Hars2provided by RGD
Official Full Name
histidyl-tRNA synthetase 2, mitochondrialprovided by RGD
Primary source
RGD:1308426
See related
EnsemblRapid:ENSRNOG00000016087 AllianceGenome:RGD:1308426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zmat2; Hars2l; RGD1308426
Summary
Predicted to enable RNA binding activity; histidine-tRNA ligase activity; and identical protein binding activity. Predicted to be involved in histidyl-tRNA aminoacylation. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human HARS2 (histidyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 147.1), Adrenal (RPKM 98.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hars2 in Genome Data Viewer
Location:
18p11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (28672810..28682367)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (28398790..28408075)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (29629203..29638460)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA72 Neighboring gene WD repeat domain 55 Neighboring gene histidyl-tRNA synthetase 1 Neighboring gene DND microRNA-mediated repression inhibitor 1 Neighboring gene protocadherin alpha 4 Neighboring gene zinc finger, matrin type 2 Neighboring gene zinc finger protein 260, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome. Pierce SB, et al. Proc Natl Acad Sci U S A, 2011 Apr 19. PMID 21464306, Free PMC Article
  2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109366

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histidine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histidine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in histidyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in histidyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable histidine--tRNA ligase, mitochondrial
Names
histidyl-tRNA synthetase 2, mitochondrial (putative)
zinc finger, matrin type 2
NP_001014034.2
XP_006254637.1
XP_038952791.1
XP_038952792.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014012.2 → NP_001014034.2  probable histidine--tRNA ligase, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    BC089973, CK481952, CV075096
    UniProtKB/TrEMBL
    A6J338, F1M9C9
    Related
    ENSRNOP00000021797.3, ENSRNOT00000021797.7
    Conserved Domains (3) summary
    COG0124
    Location:58 → 505
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cd00773
    Location:71 → 396
    HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00859
    Location:410 → 501
    HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    28672810..28682367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254575.5 → XP_006254637.1  probable histidine--tRNA ligase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZM00, A6J338
    Related
    ENSRNOP00000078926.1, ENSRNOT00000095646.2
    Conserved Domains (2) summary
    cd00773
    Location:63 → 356
    HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00859
    Location:370 → 461
    HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

  2. XM_039096864.2 → XP_038952792.1  probable histidine--tRNA ligase, mitochondrial isoform X2

    Conserved Domains (1) summary
    PLN02972
    Location:15 → 343
    PLN02972; Histidyl-tRNA synthetase

  3. XM_039096863.2 → XP_038952791.1  probable histidine--tRNA ligase, mitochondrial isoform X2

    Conserved Domains (1) summary
    PLN02972
    Location:15 → 343
    PLN02972; Histidyl-tRNA synthetase

RNA

  1. XR_005496038.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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