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Fchsd1 FCH and double SH3 domains 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307482, updated on 27-Nov-2024

Summary

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Official Symbol
Fchsd1provided by RGD
Official Full Name
FCH and double SH3 domains 1provided by RGD
Primary source
RGD:1308240
See related
EnsemblRapid:ENSRNOG00000039415 AllianceGenome:RGD:1308240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable lipid binding activity. Predicted to be involved in membrane organization; neuromuscular synaptic transmission; and positive regulation of actin filament polymerization. Predicted to be located in cuticular plate. Predicted to be active in neuromuscular junction and recycling endosome. Orthologous to human FCHSD1 (FCH and double SH3 domains 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 50.0), Brain (RPKM 48.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fchsd1 in Genome Data Viewer
Location:
18p11
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (30043466..30056326, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (29793899..29804533, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (31096815..31109077, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene diaphanous-related formin 1 Neighboring gene uncharacterized LOC120098325 Neighboring gene histone deacetylase 3 Neighboring gene RELT-like 2 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 Neighboring gene uncharacterized LOC134483010

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Formation of membrane ridges and scallops by the F-BAR protein Nervous Wreck. Becalska AN, et al. Mol Biol Cell, 2013 Aug. PMID 23761074, Free PMC Article
  2. FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro. Cao H, et al. PLoS One, 2013. PMID 23437151, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in neuromuscular synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cuticular plate ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
F-BAR and double SH3 domains protein 1
Names
FCH and double SH3 domains protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109881.3 → NP_001103351.1  F-BAR and double SH3 domains protein 1

    See identical proteins and their annotated locations for NP_001103351.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6J3E2, D4AD36
    Related
    ENSRNOP00000026381.6, ENSRNOT00000026381.9
    Conserved Domains (3) summary
    cd11761
    Location:470 → 526
    SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
    cl12013
    Location:16 → 275
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:550 → 607
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    30043466..30056326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254635.5 → XP_006254697.1  F-BAR and double SH3 domains protein 1 isoform X1

    Conserved Domains (3) summary
    cd11761
    Location:468 → 524
    SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
    cl12013
    Location:16 → 273
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:548 → 605
    SH3; Src Homology 3 domain superfamily

RNA

  1. XR_005496036.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107392.1: Suppressed sequence

    Description
    NM_001107392.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein Strain
Heading Accession and Version

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