rrm2 ribonucleotide reductase M2 polypeptide [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rrm2provided by ZNC
Official Full Name: ribonucleotide reductase M2 polypeptideprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-25
See related: Ensembl:ENSDARG00000078069 AllianceGenome:ZFIN:ZDB-GENE-990415-25
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: r2; cb111; chunp6884
Summary: Predicted to enable ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Predicted to be involved in deoxyribonucleotide biosynthetic process. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. Is expressed in several structures, including cardiovascular system; gill; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RRM2 (ribonucleotide reductase regulatory subunit M2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (47564890..47570667, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (48003903..48009649, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

multilayered mechanisms control the differential expression and function of zebrafish R2 gene during cell cycle and under genotoxic stress.
Title: Identification and characterization of alternative promoters, transcripts and protein isoforms of zebrafish R2 gene.

Submit: New GeneRIF Correction

General gene information

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Markers

rrr2 (e-PCR)
- UniSTS:187028

fc24b12.y1 (e-PCR)
- UniSTS:193189

fj44a04.x1 (e-PCR)
- UniSTS:199360

fi46a02.y1 (e-PCR)
- UniSTS:197571

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in deoxyribonucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within deoxyribonucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribonucleoside-diphosphate reductase subunit M2

Names: etID309896.20; ribonucleotide reductase protein r2 class I; ribonucleotide reductase small chain; ribonucleotide reductase small subunit

NP_571525.1

EC 1.17.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.