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Kcng2 potassium voltage-gated channel modifier subfamily G member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307234, updated on 14-Nov-2024

Summary

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Official Symbol
Kcng2provided by RGD
Official Full Name
potassium voltage-gated channel modifier subfamily G member 2provided by RGD
Primary source
RGD:1309521
See related
EnsemblRapid:ENSRNOG00000053640 AllianceGenome:RGD:1309521
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kv6.2
Summary
Enables potassium channel regulator activity. Involved in regulation of potassium ion transport. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNG2 (potassium voltage-gated channel modifier subfamily G member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 213.8), Adrenal (RPKM 29.9) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Kcng2 in Genome Data Viewer
Location:
18q12.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (76017225..76085377, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (73742224..73810420, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (76808294..76880742, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene heat shock factor binding protein 1-like 1 Neighboring gene solute carrier family 66 member 2 Neighboring gene uncharacterized LOC120098179 Neighboring gene uncharacterized LOC134482964 Neighboring gene uncharacterized LOC103694249 Neighboring gene CTD phosphatase subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural and functional characterization of Kv6.2 a new gamma-subunit of voltage-gated potassium channel. Zhu XR, et al. Recept Channels, 1999. PMID 10551266
  2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
voltage-gated potassium channel regulatory subunit KCNG2; potassium voltage-gated channel subfamily G member 2
Names
cardiac potassium channel subunit (Kv6.2)
potassium channel, voltage gated modifier subfamily G, member 2
potassium voltage-gated channel, subfamily G, member 2
voltage-gated potassium channel subunit Kv6.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107372.1 → NP_001100842.1  voltage-gated potassium channel regulatory subunit KCNG2

    See identical proteins and their annotated locations for NP_001100842.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474021
    UniProtKB/Swiss-Prot
    Q9QYU3
    UniProtKB/TrEMBL
    A6K5H5
    Related
    ENSRNOP00000069556.1, ENSRNOT00000088054.3
    Conserved Domains (2) summary
    cd18382
    Location:33 → 127
    BTB_POZ_Kv6_KCNG; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels
    pfam00520
    Location:190 → 429
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    76017225..76085377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096771.2 → XP_038952699.1  potassium voltage-gated channel subfamily G member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9QYU3
    UniProtKB/TrEMBL
    A6K5H5
    Conserved Domains (2) summary
    cd18382
    Location:33 → 127
    BTB_POZ_Kv6_KCNG; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels
    pfam00520
    Location:190 → 429
    Ion_trans; Ion transport protein

  2. XM_006254947.4 → XP_006255009.1  potassium voltage-gated channel subfamily G member 2 isoform X1

    See identical proteins and their annotated locations for XP_006255009.1

    UniProtKB/Swiss-Prot
    Q9QYU3
    UniProtKB/TrEMBL
    A6K5H5
    Conserved Domains (2) summary
    cd18382
    Location:33 → 127
    BTB_POZ_Kv6_KCNG; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels
    pfam00520
    Location:190 → 429
    Ion_trans; Ion transport protein

  3. XM_017600944.3 → XP_017456433.1  potassium voltage-gated channel subfamily G member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9QYU3
    UniProtKB/TrEMBL
    A6K5H5
    Conserved Domains (2) summary
    cd18382
    Location:33 → 127
    BTB_POZ_Kv6_KCNG; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels
    pfam00520
    Location:190 → 429
    Ion_trans; Ion transport protein

  4. XM_006254948.5 → XP_006255010.1  potassium voltage-gated channel subfamily G member 2 isoform X1

    See identical proteins and their annotated locations for XP_006255010.1

    UniProtKB/Swiss-Prot
    Q9QYU3
    UniProtKB/TrEMBL
    A6K5H5
    Conserved Domains (2) summary
    cd18382
    Location:33 → 127
    BTB_POZ_Kv6_KCNG; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels
    pfam00520
    Location:190 → 429
    Ion_trans; Ion transport protein

  5. XM_008772136.4 → XP_008770358.1  potassium voltage-gated channel subfamily G member 2 isoform X1

    See identical proteins and their annotated locations for XP_008770358.1

    UniProtKB/Swiss-Prot
    Q9QYU3
    UniProtKB/TrEMBL
    A6K5H5
    Conserved Domains (2) summary
    cd18382
    Location:33 → 127
    BTB_POZ_Kv6_KCNG; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels
    pfam00520
    Location:190 → 429
    Ion_trans; Ion transport protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYU3.1 GenPept UniProtKB/Swiss-Prot:Q9QYU3

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