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Bmi1 BMI1 proto-oncogene, polycomb ring finger [ Rattus norvegicus (Norway rat) ]

Gene ID: 307151, updated on 9-Dec-2024

Summary

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Official Symbol
Bmi1provided by RGD
Official Full Name
BMI1 proto-oncogene, polycomb ring fingerprovided by RGD
Primary source
RGD:1307403
See related
EnsemblRapid:ENSRNOG00000016585 AllianceGenome:RGD:1307403
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pcgf4
Summary
Predicted to enable several functions, including RING-like zinc finger domain binding activity; promoter-specific chromatin binding activity; and zinc ion binding activity. Involved in cellular response to dexamethasone stimulus; cellular response to interleukin-1; and regulation of kidney development. Predicted to be located in cytosol; heterochromatin; and nuclear body. Predicted to be part of PRC1 complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; hepatocellular carcinoma; and renal Wilms' tumor. Orthologous to several human genes including BMI1 (BMI1 proto-oncogene, polycomb ring finger). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 131.8), Heart (RPKM 108.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bmi1 in Genome Data Viewer
Location:
17q12.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (86240683..86250044)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (81332175..81341625)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (85360439..85370283)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482616 Neighboring gene COMM domain containing 3 Neighboring gene sperm associated antigen 6 Neighboring gene uncharacterized LOC120097847

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The poor outcome of second primary oral squamous cell carcinoma is attributed to Bmi1 upregulation. Hu Q, et al. Cancer Med, 2018 Apr. PMID 29479858, Free PMC Article
  2. Localization of Bmi1 in osteoblast-lineage cells during endochondral ossification. Takebe H, et al. Anat Rec (Hoboken), 2022 May. PMID 34101367
  3. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. van der Lugt NM, et al. Genes Dev, 1994 Apr 1. PMID 7926765
  4. BMI-1 is highly expressed in M0-subtype acute myeloid leukemia. Sawa M, et al. Int J Hematol, 2005 Jul. PMID 16105758
  5. Differentiation of postnatal cerebellar glial progenitors is controlled by Bmi1 through BMP pathway inhibition. Zhang X, et al. Glia, 2011 Jul. PMID 21544870

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Localization of Bmi1 in osteoblast-lineage cells during endochondral ossification.
    Title: Localization of Bmi1 in osteoblast-lineage cells during endochondral ossification.
  2. In a rat model of radiotherapy-induced mucositis, Bmi1 upregulation was observed 8 days after irradiation. Consistently, Bmi1 was upregulated in HaCaT cells 1 h after irradiation, and its upregulation was in accord with X-ray exposure duration. the prognosis of s-OSCC is poorer as compared to p-OSCC, which may be attributed to Bmi1 upregulation.
    Title: The poor outcome of second primary oral squamous cell carcinoma is attributed to Bmi1 upregulation.
  3. We conclude that silencing of Bmi1 by miR-27b relieves repression of the presynaptic transcriptome and supports neurotransmission in cortical networks.
    Title: miR-27b shapes the presynaptic transcriptome and influences neurotransmission by silencing the polycomb group protein Bmi1.
  4. Thus modulation of Bmi1 expression in glial progenitors may represent a key event in determining the differentiation potential of these cells.
    Title: Differentiation of postnatal cerebellar glial progenitors is controlled by Bmi1 through BMP pathway inhibition.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RING-like zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA methylation-dependent constitutive heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within chromatin organization ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic skeletal system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within humoral immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of immature T cell proliferation in thymus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of adaxial/abaxial pattern formation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of kidney development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within rostrocaudal neural tube patterning ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somatic stem cell division ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of PRC1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polycomb complex protein BMI-1
Names
B lymphoma Mo-MLV insertion region 1
Bmi1 polycomb ring finger oncogene
polycomb group ring finger 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107368.2 → NP_001100838.1  polycomb complex protein BMI-1

    See identical proteins and their annotated locations for NP_001100838.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168209
    UniProtKB/TrEMBL
    A6JM95, B4F7B6, F7FA44
    Related
    ENSRNOP00000103433.1, ENSRNOT00000126368.1
    Conserved Domains (3) summary
    PRK10803
    Location:222 → 279
    PRK10803; tol-pal system protein YbgF; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17165
    Location:130 → 224
    RAWUL_PCGF4; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 4 (PCGF4)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    86240683..86250044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095805.2 → XP_038951733.1  polycomb complex protein BMI-1 isoform X1

    UniProtKB/TrEMBL
    A6JM95, B4F7B6, F7FA44
    Related
    ENSRNOP00000059998.2, ENSRNOT00000064257.4
    Conserved Domains (3) summary
    PRK10803
    Location:222 → 279
    PRK10803; tol-pal system protein YbgF; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17165
    Location:130 → 224
    RAWUL_PCGF4; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 4 (PCGF4)

  2. XM_063276500.1 → XP_063132570.1  polycomb complex protein BMI-1 isoform X1

    UniProtKB/TrEMBL
    A6JM95, B4F7B6, F7FA44

  3. XM_039095806.2 → XP_038951734.1  polycomb complex protein BMI-1 isoform X1

    UniProtKB/TrEMBL
    A6JM95, B4F7B6, F7FA44
    Conserved Domains (3) summary
    PRK10803
    Location:222 → 279
    PRK10803; tol-pal system protein YbgF; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17165
    Location:130 → 224
    RAWUL_PCGF4; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 4 (PCGF4)

  4. XM_039095807.2 → XP_038951735.1  polycomb complex protein BMI-1 isoform X1

    UniProtKB/TrEMBL
    A6JM95, B4F7B6, F7FA44
    Conserved Domains (3) summary
    PRK10803
    Location:222 → 279
    PRK10803; tol-pal system protein YbgF; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17165
    Location:130 → 224
    RAWUL_PCGF4; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 4 (PCGF4)

  5. XM_039095808.2 → XP_038951736.1  polycomb complex protein BMI-1 isoform X1

    UniProtKB/TrEMBL
    A6JM95, B4F7B6, F7FA44
    Conserved Domains (3) summary
    PRK10803
    Location:222 → 279
    PRK10803; tol-pal system protein YbgF; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17165
    Location:130 → 224
    RAWUL_PCGF4; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 4 (PCGF4)

  6. XM_063276501.1 → XP_063132571.1  polycomb complex protein BMI-1 isoform X1

    UniProtKB/TrEMBL
    A6JM95, B4F7B6, F7FA44
Nucleotide Protein Strain
Heading Accession and Version

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