U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

snap25a synaptosome associated protein 25a [ Danio rerio (zebrafish) ]

Gene ID: 30712, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
snap25aprovided by ZNC
Official Full Name
synaptosome associated protein 25aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-468
See related
Ensembl:ENSDARG00000020609 AllianceGenome:ZFIN:ZDB-GENE-980526-468
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Snap; snap25; fj42b02; fj45g04; fj48c02; snap25.1; wu:fj42b02; wu:fj45g04; wu:fj48c02
Summary
Predicted to enable SNAP receptor activity and syntaxin-1 binding activity. Acts upstream of or within locomotory behavior and mitotic cytokinesis. Located in plasma membrane. Is expressed in head; nervous system; and optic vesicle. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to human SNAP25 (synaptosome associated protein 25). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See snap25a in Genome Data Viewer
Location:
chromosome: 20
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (34913069..34956043)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (35010157..35056189)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene elastin microfibril interfacer 1a Neighboring gene ankyrin repeat and EF-hand domain containing 1a Neighboring gene saccharopine dehydrogenase b Neighboring gene uncharacterized LOC110438184 Neighboring gene consortin, connexin sorting protein b

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Replacing SNAP-25b with SNAP-25a expression results in metabolic disease. Valladolid-Acebes I, et al. Proc Natl Acad Sci U S A, 2015 Aug 4. PMID 26195742, Free PMC Article
  2. RBFOX1 and Working Memory: From Genome to Transcriptome Revealed Posttranscriptional Mechanism Separate From Attention-Deficit/Hyperactivity Disorder. Zhong Y, et al. Biol Psychiatry Glob Open Sci, 2023 Oct. PMID 37881587, Free PMC Article
  3. Recruitment and SNARE-mediated fusion of vesicles in furrow membrane remodeling during cytokinesis in zebrafish embryos. Li WM, et al. Exp Cell Res, 2006 Oct 15. PMID 16876784
  4. miR-153 regulates SNAP-25, synaptic transmission, and neuronal development. Wei C, et al. PLoS One, 2013. PMID 23451149, Free PMC Article
  5. Spatiotemporal expression profile of embryonic and adult ankyrin repeat and EF-hand domain containing protein 1-encoding genes ankef1a and ankef1b in zebrafish. Daniel JG, et al. Gene Expr Patterns, 2019 Dec. PMID 31520739

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular analysis of ndrg4 mutants shows that expression of snap25 and nsf are sharply decreased, revealing a role of ndrg4 in controlling vesicle exocytosis. This uncovers a previously unknown function of ndrg4 in regulating vesicle docking and nodes of Ranvier organization, at least through its ability to finely tune the expression of the t-SNARE/NSF machinery.
    Title: Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish.
  2. a mouse mutant engineered to express normal levels of SNAP-25 but only SNAP-25a shows metabolic disease.
    Title: Replacing SNAP-25b with SNAP-25a expression results in metabolic disease.
  3. results indicate that precise control of SNAP-25 expression by miR-153 is critically important for proper neuronal patterning as well as neurotransmission
    Title: miR-153 regulates SNAP-25, synaptic transmission, and neuronal development.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IEA
Inferred from Electronic Annotation
more info
  
enables syntaxin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin-1 binding IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of BLOC-1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of SNARE complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
synaptosomal-associated protein 25-A
Names
etID17571.20
etID69167.20
synaptosomal-associated protein, 25a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131435.1 → NP_571510.1  synaptosomal-associated protein 25-A

    See identical proteins and their annotated locations for NP_571510.1

    Status: PROVISIONAL

    Source sequence(s)
    BC063942
    UniProtKB/Swiss-Prot
    Q5TZ66
    Related
    ENSDARP00000019054.5, ENSDART00000007584.8
    Conserved Domains (3) summary
    cd15885
    Location:141 → 199
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:10 → 82
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91 → 139
    SNAP-25; SNAP-25 family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    34913069..34956043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160623.5 → XP_005160680.1  synaptosomal-associated protein 25-A isoform X1

    UniProtKB/Swiss-Prot
    Q5TZ66
    Related
    ENSDARP00000062737.6, ENSDART00000062738.7
    Conserved Domains (3) summary
    cd15885
    Location:141 → 199
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:10 → 82
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91 → 139
    SNAP-25; SNAP-25 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5TZ66.1 GenPept UniProtKB/Swiss-Prot:Q5TZ66

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous