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Net1 neuroepithelial cell transforming 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307098, updated on 14-Nov-2024

Summary

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Official Symbol
Net1provided by RGD
Official Full Name
neuroepithelial cell transforming 1provided by RGD
Primary source
RGD:1305034
See related
EnsemblRapid:ENSRNOG00000017765 AllianceGenome:RGD:1305034
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including cellular response to hydrogen peroxide; positive regulation of GTPase activity; and positive regulation of Rho protein signal transduction. Predicted to act upstream of or within myoblast migration. Predicted to be located in cytoplasm. Orthologous to human NET1 (neuroepithelial cell transforming 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 413.1), Lung (RPKM 408.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Net1 in Genome Data Viewer
Location:
17q12.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (71251145..71280345)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (66341251..66370445)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (69991786..70020977)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene urocortin 3 Neighboring gene tubulin, alpha-like 3 Neighboring gene uncharacterized LOC134482593 Neighboring gene uncharacterized LOC134482594 Neighboring gene uncharacterized LOC103694125

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rac1 controls the subcellular localization of the Rho guanine nucleotide exchange factor Net1A to regulate focal adhesion formation and cell spreading. Carr HS, et al. Mol Cell Biol, 2013 Feb. PMID 23184663, Free PMC Article
  2. The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage. Srougi MC, et al. PLoS One, 2011 Feb 23. PMID 21373644, Free PMC Article
  3. Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation. Hu JK, et al. Genes Dev, 2012 Sep 15. PMID 22987639, Free PMC Article
  4. The sclerostin-bone protein interactome. Devarajan-Ketha H, et al. Biochem Biophys Res Commun, 2012 Jan 13. PMID 22206666, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC114559

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within myoblast migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neuroepithelial cell-transforming gene 1 protein
Names
neuroepithelial cell transforming gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039023.1 → NP_001034112.1  neuroepithelial cell-transforming gene 1 protein

    See identical proteins and their annotated locations for NP_001034112.1

    Status: PROVISIONAL

    Source sequence(s)
    BC100154
    UniProtKB/TrEMBL
    A6JLQ2, Q498M6
    Related
    ENSRNOP00000023945.2, ENSRNOT00000023945.6
    Conserved Domains (3) summary
    smart00325
    Location:124 → 300
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13224
    Location:314 → 448
    PH_Net1; Neuroepithelial cell transforming 1 Pleckstrin homology (PH) domain
    pfam00169
    Location:333 → 447
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    71251145..71280345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254206.5 → XP_006254268.1  neuroepithelial cell-transforming gene 1 protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6AVA8
    Related
    ENSRNOP00000102206.1, ENSRNOT00000170244.1
    Conserved Domains (3) summary
    smart00325
    Location:178 → 354
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13224
    Location:368 → 502
    PH_Net1; Neuroepithelial cell transforming 1 Pleckstrin homology (PH) domain
    pfam00169
    Location:387 → 501
    PH; PH domain
Nucleotide Protein Strain
Heading Accession and Version

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