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nkx2.5 - NK2 homeobox 5

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including circulatory system development; embryonic viscerocranium morphogenesis; and regulation of cardiac chamber formation. Predicted to be active in nucleus. Is expressed in several structures, including cardiac muscle myoblast; cardiovascular system; digestive system; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in aortic valve disease 2; atrioventricular block; congenital heart disease (multiple); and congenital nongoitrous hypothyroidism 5. Orthologous to human NKX2-5 (NK2 homeobox 5). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to nkx2.5

NCBI Orthologs

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Species Gene Architecture aa