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Wnk2 WNK lysine deficient protein kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306811, updated on 14-Nov-2024

Summary

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Official Symbol
Wnk2provided by RGD
Official Full Name
WNK lysine deficient protein kinase 2provided by RGD
Primary source
RGD:1307284
See related
EnsemblRapid:ENSRNOG00000016684 AllianceGenome:RGD:1307284
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307284
Summary
Predicted to enable potassium channel inhibitor activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including protein autophosphorylation; regulation of metal ion transport; and regulation of signal transduction. Predicted to be active in cytosol. Biomarker of transient cerebral ischemia. Orthologous to human WNK2 (WNK lysine deficient protein kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 48.5), Muscle (RPKM 36.0) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wnk2 in Genome Data Viewer
Location:
17p14
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (15709648..15818874)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (15503672..15612479)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (15923508..16032271)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family, member 19 Neighboring gene ninjurin 1 Neighboring gene transfer RNA alanine (anticodon UGC) 8 Neighboring gene uncharacterized LOC134482822

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CircRNA-WNK2 Acts as a ceRNA for miR-328a-3p to Promote AANAT Expression in the Male Rat Pineal Gland. Zheng Y, et al. Endocrinology, 2022 Feb 1. PMID 34918065
  2. Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2. Moniz S, et al. Oncogene, 2007 Sep 6. PMID 17667937
  3. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. Bhuiyan MIH, et al. J Cereb Blood Flow Metab, 2017 Aug. PMID 27798271, Free PMC Article
  4. WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. Rinehart J, et al. J Biol Chem, 2011 Aug 26. PMID 21733846, Free PMC Article
  5. Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling. Serysheva E, et al. EMBO Rep, 2013 Aug. PMID 23797875, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircRNA-WNK2 Acts as a ceRNA for miR-328a-3p to Promote AANAT Expression in the Male Rat Pineal Gland.
    Title: CircRNA-WNK2 Acts as a ceRNA for miR-328a-3p to Promote AANAT Expression in the Male Rat Pineal Gland.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase WNK2
Names
kinase deficient protein
NP_001178485.1
XP_006253777.1
XP_017456004.1
XP_017456005.1
XP_038951586.1
XP_038951593.1
XP_063132425.1
XP_063132426.1
XP_063132427.1
XP_063132428.1
XP_063132429.1
XP_063132430.1
XP_063132431.1
XP_063132432.1
XP_063132433.1
XP_063132434.1
XP_063132435.1
XP_063132436.1
XP_063132437.1
XP_063132438.1
XP_063132439.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191556.1 → NP_001178485.1  serine/threonine-protein kinase WNK2

    See identical proteins and their annotated locations for NP_001178485.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    D3ZMJ7
    Related
    ENSRNOP00000039118.5, ENSRNOT00000050696.7
    Conserved Domains (3) summary
    PHA03247
    Location:700 → 1085
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    15709648..15818874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276357.1 → XP_063132427.1  serine/threonine-protein kinase WNK2 isoform X4

  2. XM_063276358.1 → XP_063132428.1  serine/threonine-protein kinase WNK2 isoform X8

  3. XM_063276356.1 → XP_063132426.1  serine/threonine-protein kinase WNK2 isoform X3

  4. XM_063276355.1 → XP_063132425.1  serine/threonine-protein kinase WNK2 isoform X2

  5. XM_063276362.1 → XP_063132432.1  serine/threonine-protein kinase WNK2 isoform X12

  6. XM_063276359.1 → XP_063132429.1  serine/threonine-protein kinase WNK2 isoform X9

  7. XM_006253715.5 → XP_006253777.1  serine/threonine-protein kinase WNK2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AC38, D3ZMJ7
    Conserved Domains (3) summary
    smart00220
    Location:200 → 453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  8. XM_063276364.1 → XP_063132434.1  serine/threonine-protein kinase WNK2 isoform X15

  9. XM_063276367.1 → XP_063132437.1  serine/threonine-protein kinase WNK2 isoform X18

  10. XM_063276369.1 → XP_063132439.1  serine/threonine-protein kinase WNK2 isoform X20

  11. XM_063276361.1 → XP_063132431.1  serine/threonine-protein kinase WNK2 isoform X11

  12. XM_039095658.2 → XP_038951586.1  serine/threonine-protein kinase WNK2 isoform X5

    UniProtKB/TrEMBL
    D3ZMJ7
    Conserved Domains (3) summary
    PHA03247
    Location:700 → 1085
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  13. XM_063276363.1 → XP_063132433.1  serine/threonine-protein kinase WNK2 isoform X13

    UniProtKB/TrEMBL
    A0A8I5ZXV8
    Related
    ENSRNOP00000084430.1, ENSRNOT00000115946.2

  14. XM_039095665.2 → XP_038951593.1  serine/threonine-protein kinase WNK2 isoform X14

    UniProtKB/TrEMBL
    D3ZMJ7
    Conserved Domains (3) summary
    PHA03247
    Location:700 → 1085
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  15. XM_063276366.1 → XP_063132436.1  serine/threonine-protein kinase WNK2 isoform X17

    Related
    ENSRNOP00000081251.2, ENSRNOT00000094776.2

  16. XM_017600516.3 → XP_017456005.1  serine/threonine-protein kinase WNK2 isoform X7

    UniProtKB/TrEMBL
    D3ZMJ7
    Related
    ENSRNOP00000079712.2, ENSRNOT00000117530.2
    Conserved Domains (3) summary
    smart00220
    Location:200 → 453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  17. XM_063276360.1 → XP_063132430.1  serine/threonine-protein kinase WNK2 isoform X10

    UniProtKB/TrEMBL
    A0A8I6APM9
    Related
    ENSRNOP00000096453.1, ENSRNOT00000117974.2

  18. XM_063276365.1 → XP_063132435.1  serine/threonine-protein kinase WNK2 isoform X16

  19. XM_017600515.3 → XP_017456004.1  serine/threonine-protein kinase WNK2 isoform X6

    UniProtKB/TrEMBL
    A0A0G2KAS8, D3ZMJ7
    Related
    ENSRNOP00000075510.2, ENSRNOT00000084304.3
    Conserved Domains (3) summary
    smart00220
    Location:200 → 453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  20. XM_063276368.1 → XP_063132438.1  serine/threonine-protein kinase WNK2 isoform X19

Nucleotide Protein Strain
Heading Accession and Version

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