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Rmi1 RecQ mediated genome instability 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306734, updated on 27-Nov-2024

Summary

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Official Symbol
Rmi1provided by RGD
Official Full Name
RecQ mediated genome instability 1provided by RGD
Primary source
RGD:1310671
See related
EnsemblRapid:ENSRNOG00000019108 AllianceGenome:RGD:1310671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310671
Summary
Predicted to enable nucleotide binding activity. Predicted to be involved in double-strand break repair via homologous recombination; resolution of DNA recombination intermediates; and resolution of meiotic recombination intermediates. Predicted to act upstream of or within glucose homeostasis; reduction of food intake in response to dietary excess; and response to glucose. Predicted to be located in nucleoplasm. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in nuclear body. Orthologous to human RMI1 (RecQ mediated genome instability 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 75.5), Thymus (RPKM 74.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rmi1 in Genome Data Viewer
Location:
17p14
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (6261961..6269947, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (6256533..6264523, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (6658285..6665618, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482765 Neighboring gene uncharacterized LOC120097836 Neighboring gene heterogeneous nuclear ribonucleoprotein K Neighboring gene microRNA 7-1 Neighboring gene Q-nucleotide N-glycosylase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RMI1 deficiency in mice protects from diet and genetic-induced obesity. Suwa A, et al. FEBS J, 2010 Feb. PMID 20050919
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within reduction of food intake in response to dietary excess ISO
Inferred from Sequence Orthology
more info
  
involved_in resolution of DNA recombination intermediates ISO
Inferred from Sequence Orthology
more info
  
involved_in resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to dietary excess ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to glucose ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RecQ family helicase-topoisomerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RecQ family helicase-topoisomerase III complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
recQ-mediated genome instability protein 1
Names
RMI1, RecQ mediated genome instability 1, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400626.1 → NP_001387555.1  recQ-mediated genome instability protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    D3ZHX4

  2. NM_001400627.1 → NP_001387556.1  recQ-mediated genome instability protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    D3ZHX4
    Related
    ENSRNOP00000087376.1, ENSRNOT00000095008.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    6261961..6269947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096370.2 → XP_038952298.1  recQ-mediated genome instability protein 1 isoform X1

    UniProtKB/TrEMBL
    D3ZHX4
    Related
    ENSRNOP00000025812.4, ENSRNOT00000025812.8
    Conserved Domains (2) summary
    pfam08585
    Location:14 → 204
    RMI1_N; RecQ mediated genome instability protein
    pfam16099
    Location:481 → 611
    RMI1_C; Recq-mediated genome instability protein 1, C-terminal OB-fold

  2. XM_039096368.2 → XP_038952296.1  recQ-mediated genome instability protein 1 isoform X1

    UniProtKB/TrEMBL
    D3ZHX4
    Conserved Domains (2) summary
    pfam08585
    Location:14 → 204
    RMI1_N; RecQ mediated genome instability protein
    pfam16099
    Location:481 → 611
    RMI1_C; Recq-mediated genome instability protein 1, C-terminal OB-fold

  3. XM_039096367.1 → XP_038952295.1  recQ-mediated genome instability protein 1 isoform X1

    UniProtKB/TrEMBL
    D3ZHX4
    Conserved Domains (2) summary
    pfam08585
    Location:14 → 204
    RMI1_N; RecQ mediated genome instability protein
    pfam16099
    Location:481 → 611
    RMI1_C; Recq-mediated genome instability protein 1, C-terminal OB-fold

  4. XM_006253566.5 → XP_006253628.1  recQ-mediated genome instability protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006253628.1

    UniProtKB/TrEMBL
    D3ZHX4
    Related
    ENSRNOP00000083874.1, ENSRNOT00000097627.2
    Conserved Domains (2) summary
    pfam08585
    Location:14 → 204
    RMI1_N; RecQ mediated genome instability protein
    pfam16099
    Location:481 → 611
    RMI1_C; Recq-mediated genome instability protein 1, C-terminal OB-fold

  5. XM_063276333.1 → XP_063132403.1  recQ-mediated genome instability protein 1 isoform X1

    UniProtKB/TrEMBL
    D3ZHX4
    Related
    ENSRNOP00000081721.1, ENSRNOT00000102406.2
Nucleotide Protein Strain
Heading Accession and Version

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