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Tent4a terminal nucleotidyltransferase 4A [ Rattus norvegicus (Norway rat) ]

Gene ID: 306672, updated on 27-Nov-2024

Summary

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Official Symbol
Tent4aprovided by RGD
Official Full Name
terminal nucleotidyltransferase 4Aprovided by RGD
Primary source
RGD:1307356
See related
EnsemblRapid:ENSRNOG00000017613 AllianceGenome:RGD:1307356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pols; Papd7
Summary
Predicted to enable guanylyltransferase activity and poly(A) RNA polymerase activity. Predicted to be involved in RNA metabolic process; regulation of mRNA stability; and response to xenobiotic stimulus. Predicted to be located in Golgi apparatus; nuclear membrane; and nucleoplasm. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Orthologous to human TENT4A (terminal nucleotidyltransferase 4A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 45.1), Kidney (RPKM 42.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tent4a in Genome Data Viewer
Location:
1p11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (35594380..35627836)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (33765949..33799405)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (36400056..36433238)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene steroid 5 alpha-reductase 1 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene Rab geranylgeranyltransferase subunit beta, pseudogene 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 18 Neighboring gene Myc binding protein, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation. Lim J, et al. Science, 2018 Aug 17. PMID 30026317
  2. The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin. Walowsky C, et al. J Biol Chem, 1999 Mar 12. PMID 10066793
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA 3' uridylation ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
  
involved_in polyadenylation-dependent ncRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of TRAMP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
terminal nucleotidyltransferase 4A
Names
DNA polymerase sigma
PAP associated domain containing 7
non-canonical poly(A) RNA polymerase PAPD7
poly(A) RNA polymerase D7, non-canonical
polymerase (DNA directed) sigma
NP_001100803.2
NP_001402773.1
XP_038966019.1
XP_063144175.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107333.3 → NP_001100803.2  terminal nucleotidyltransferase 4A isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    D3ZSY1

  2. NM_001415844.1 → NP_001402773.1  terminal nucleotidyltransferase 4A isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Related
    ENSRNOP00000023712.7, ENSRNOT00000023712.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    35594380..35627836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288105.1 → XP_063144175.1  terminal nucleotidyltransferase 4A isoform X1

    Related
    ENSRNOP00000103767.1, ENSRNOT00000128302.1

  2. XM_039110091.2 → XP_038966019.1  terminal nucleotidyltransferase 4A isoform X2

    UniProtKB/TrEMBL
    A6JV21
    Conserved Domains (2) summary
    COG5260
    Location:2 → 295
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    pfam05109
    Location:370 → 473
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
Nucleotide Protein Strain
Heading Accession and Version

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