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Ckap2 cytoskeleton associated protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306575, updated on 27-Nov-2024

Summary

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Official Symbol
Ckap2provided by RGD
Official Full Name
cytoskeleton associated protein 2provided by RGD
Primary source
RGD:1311631
See related
EnsemblRapid:ENSRNOG00000024650 AllianceGenome:RGD:1311631
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in negative regulation of microtubule depolymerization. Predicted to act upstream of or within mitotic cytokinesis and positive regulation of transcription by RNA polymerase II. Predicted to be located in centrosome and mitotic spindle. Predicted to be active in microtubule cytoskeleton. Orthologous to human CKAP2 (cytoskeleton associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 92.7), Spleen (RPKM 69.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ckap2 in Genome Data Viewer
Location:
16q12.5
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (76542114..76567297)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (69839668..69864852)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (74752655..74779184)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene thrombospondin type 1 domain containing 1 Neighboring gene vacuolar protein sorting 36 homolog Neighboring gene NIMA-related kinase 3 Neighboring gene NIMA-related kinase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. Tsuchihara K, et al. Cancer Res, 2005 Aug 1. PMID 16061649
  2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytoskeleton-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001169139.1 → NP_001162610.1  cytoskeleton-associated protein 2

    Status: VALIDATED

    Source sequence(s)
    CK596035, EV774137, EV778235, JAXUCZ010000016
    UniProtKB/TrEMBL
    A6IW82, D3ZPD0
    Related
    ENSRNOP00000037955.4, ENSRNOT00000029266.7
    Conserved Domains (1) summary
    pfam15297
    Location:326 → 663
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    76542114..76567297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094590.2 → XP_038950518.1  cytoskeleton-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    A6IW82
    Conserved Domains (1) summary
    pfam15297
    Location:262 → 596
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

  2. XM_039094591.2 → XP_038950519.1  cytoskeleton-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    A6IW82
    Conserved Domains (1) summary
    pfam15297
    Location:262 → 596
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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