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mtch2 mitochondrial carrier homolog 2 [ Danio rerio (zebrafish) ]

Gene ID: 30655, updated on 9-Dec-2024

Summary

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Official Symbol
mtch2provided by ZNC
Official Full Name
mitochondrial carrier homolog 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-991008-9
See related
Ensembl:ENSDARG00000019732 AllianceGenome:ZFIN:ZDB-GENE-991008-9
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi20c06; fj35g12; wu:fi20c06; wu:fj35g12
Summary
Involved in adipose tissue development. Acts upstream of or within digestive tract development; fat cell differentiation; and liver development. Predicted to be located in mitochondrial outer membrane. Predicted to be active in membrane and mitochondrion. Is expressed in several structures, including central nervous system; head; liver; male organism; and pleuroperitoneal region. Orthologous to human MTCH2 (mitochondrial carrier 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See mtch2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (38667111..38678090)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (38395856..38406831)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene nephrosin Neighboring gene six-cysteine containing astacin protease 1 Neighboring gene proteasome 26S subunit, ATPase 3 Neighboring gene uncharacterized LOC137496187 Neighboring gene apelin receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Loss of mtch2 function impairs early development of liver, intestine and visceral adipocytes in zebrafish larvae. Landgraf K, et al. FEBS Lett, 2016 Sep. PMID 27468124
  2. Evolution of teleostean hatching enzyme genes and their paralogous genes. Kawaguchi M, et al. Dev Genes Evol, 2006 Dec. PMID 17016731
  3. Identification of differentially expressed genes between cloned and zygote-developing zebrafish (Danio rerio) embryos at the dome stage using suppression subtractive hybridization. Luo D, et al. Biol Reprod, 2009 Apr. PMID 19092113
  4. Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Zhang J, et al. Front Endocrinol (Lausanne), 2018. PMID 30631305, Free PMC Article
  5. Expression and regulation of drug transporters in vertebrate neutrophils. Foulkes MJ, et al. Sci Rep, 2017 Jul 10. PMID 28694436, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The findings indicate an essential role for mtch2 during organ development and adipogenesis in vivo.
    Title: Loss of mtch2 function impairs early development of liver, intestine and visceral adipocytes in zebrafish larvae.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in adipose tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitochondrial carrier homolog 2
Names
etID15240.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131382.1 → NP_571457.1  mitochondrial carrier homolog 2

    See identical proteins and their annotated locations for NP_571457.1

    Status: PROVISIONAL

    Source sequence(s)
    AF176010
    UniProtKB/TrEMBL
    F6P3G0, Q789I7, Q9PUL9
    Related
    ENSDARP00000016602.5, ENSDART00000013394.6
    Conserved Domains (1) summary
    pfam00153
    Location:125 → 189
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    38667111..38678090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477393.2 → XP_021333068.1  mitochondrial carrier homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q165
    Conserved Domains (1) summary
    pfam00153
    Location:124 → 188
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version

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