Plpbp pyridoxal phosphate binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plpbpprovided by RGD
Official Full Name: pyridoxal phosphate binding proteinprovided by RGD
Primary source: RGD:1308962
See related: EnsemblRapid:ENSRNOG00000013751 AllianceGenome:RGD:1308962
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Prosc
Summary: Predicted to enable pyridoxal phosphate binding activity. Predicted to be involved in vitamin B6 metabolic process. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in early-onset vitamin B6-dependent epilepsy 1. Orthologous to human PLPBP (pyridoxal phosphate binding protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Kidney (RPKM 500.7), Heart (RPKM 179.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (71705064..71717726, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (65003292..65014886, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (69164654..69176245, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

WI-15099 (e-PCR)
- UniSTS:18470

RH127692 (e-PCR)
- UniSTS:211002

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in vitamin B6 metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: pyridoxal phosphate homeostasis protein

Names: proline synthase co-transcribed bacterial homolog protein; proline synthetase co-transcribed homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107320.1 → NP_001100790.1 pyridoxal phosphate homeostasis protein

See identical proteins and their annotated locations for NP_001100790.1

Status: PROVISIONAL

Source sequence(s)

CH473970

UniProtKB/TrEMBL

A0A8I5YBG7, A6IVY3, D3ZCA0

Related

ENSRNOP00000076766.2, ENSRNOT00000098394.2

Conserved Domains (1) summary

cd06822
Location:17 → 248

PLPDE_III_YBL036c_euk; Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Eukaryotic YBL036c-like proteins