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Mtus1 microtubule associated scaffold protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306487, updated on 27-Nov-2024

Summary

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Symbol
Mtus1provided by RGD
Full Name
microtubule associated scaffold protein 1provided by RGD
Primary source
RGD:631381
See related
EnsemblRapid:ENSRNOG00000010748 AllianceGenome:RGD:631381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ATIP4; Mtsg1; Atip3b
Summary
Predicted to enable microtubule binding activity. Involved in cellular response to angiotensin. Predicted to be located in microtubule cytoskeleton and nucleolus. Predicted to be active in nucleus. Predicted to colocalize with cytoplasm. Orthologous to human MTUS1 (microtubule associated scaffold protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 617.5), Adrenal (RPKM 314.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtus1 in Genome Data Viewer
Location:
16q12.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (57905991..58051466)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (51202497..51347794)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (54240892..54386131)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene pericentriolar material 1 Neighboring gene fibrinogen-like 1 Neighboring gene uncharacterized LOC103693968 Neighboring gene uncharacterized LOC120097427 Neighboring gene uncharacterized LOC120097428 Neighboring gene platelet-derived growth factor receptor-like Neighboring gene elongin B, pseduogene 1 Neighboring gene solute carrier family 7 member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Function and expression of ATIP and its variants in cardiomyoblast cell line H9c2. Varghayee N, et al. J Renin Angiotensin Aldosterone Syst, 2015 Mar. PMID 23559668
  2. Gene sequencing and tissue expression of unknown isoforms of an angiotensin II type 2 receptor interacting protein, ATIP, in the rat. Krezel MA, et al. Biosci Biotechnol Biochem, 2011. PMID 21389599
  3. MTUS1/ATIP3a down-regulation is associated with enhanced migration, invasion and poor prognosis in salivary adenoid cystic carcinoma. Zhao T, et al. BMC Cancer, 2015 Mar 31. PMID 25885343, Free PMC Article
  4. Identification of a new tumor suppressor gene located at chromosome 8p21.3-22. Seibold S, et al. FASEB J, 2003 Jun. PMID 12692079
  5. Regulation of transport of the angiotensin AT2 receptor by a novel membrane-associated Golgi protein. Wruck CJ, et al. Arterioscler Thromb Vasc Biol, 2005 Jan. PMID 15539617

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This is the first report to identify that ATIP may have a similar role in other disease states characterised by excessive growth
    Title: Function and expression of ATIP and its variants in cardiomyoblast cell line H9c2.
  2. Expression levels of isoformes ATIP3 and ATIP4 in rat tissues were examined. There was little similarity in the relative tissue distribution of the various ATIP isoforms in rat and human
    Title: Gene sequencing and tissue expression of unknown isoforms of an angiotensin II type 2 receptor interacting protein, ATIP, in the rat.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to angiotensin IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to peptide hormone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
microtubule-associated tumor suppressor 1 homolog
Names
angiotensin-II type 2 receptor-interacting protein
growth factor inhibitor
microtubule associated tumor suppressor 1
mitochondrial tumor suppressor 1
transcription factor MTSG1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395000.1 → NP_001381929.1  microtubule-associated tumor suppressor 1 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    B1A2U8
    Related
    ENSRNOP00000069962.1, ENSRNOT00000079006.3
    Conserved Domains (1) summary
    TIGR02168
    Location:835 → 1154
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. NM_178093.2 → NP_835194.2  microtubule-associated tumor suppressor 1 homolog isoform 2

    See identical proteins and their annotated locations for NP_835194.2

    Status: VALIDATED

    Source sequence(s)
    BC072537
    UniProtKB/Swiss-Prot
    Q6IMY1, Q6XUU5, Q80Z99
    UniProtKB/TrEMBL
    A6JPU4, I7GGY1
    Related
    ENSRNOP00000030995.2, ENSRNOT00000037685.7
    Conserved Domains (1) summary
    TIGR02168
    Location:66 → 385
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    57905991..58051466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253181.5 → XP_006253243.1  microtubule-associated tumor suppressor 1 homolog isoform X1

    See identical proteins and their annotated locations for XP_006253243.1

    UniProtKB/TrEMBL
    B1A2U8
    Conserved Domains (1) summary
    TIGR02168
    Location:835 → 1154
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_063275428.1 → XP_063131498.1  microtubule-associated tumor suppressor 1 homolog isoform X1

  3. XM_017600120.3 → XP_017455609.1  microtubule-associated tumor suppressor 1 homolog isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZY91, I7GGY1
    Related
    ENSRNOP00000102205.1, ENSRNOT00000153250.1

  4. XM_006253182.5 → XP_006253244.1  microtubule-associated tumor suppressor 1 homolog isoform X2

    See identical proteins and their annotated locations for XP_006253244.1

    UniProtKB/TrEMBL
    D2XRB8
    Related
    ENSRNOP00000070944.1, ENSRNOT00000090266.3
    Conserved Domains (2) summary
    pfam09755
    Location:193 → 460
    DUF2046; Uncharacterized conserved protein H4 (DUF2046)
    cl19219
    Location:330 → 406
    DUF342; Protein of unknown function (DUF342)

  5. XM_017600121.3 → XP_017455610.1  microtubule-associated tumor suppressor 1 homolog isoform X4

    UniProtKB/TrEMBL
    I7GGY1

  6. XM_017600122.3 → XP_017455611.1  microtubule-associated tumor suppressor 1 homolog isoform X5

    UniProtKB/TrEMBL
    A0A8L2QL23, I7GGY1

  7. XM_039094527.2 → XP_038950455.1  microtubule-associated tumor suppressor 1 homolog isoform X6

    Related
    ENSRNOP00000084500.2, ENSRNOT00000102597.2
    Conserved Domains (1) summary
    TIGR02168
    Location:14 → 291
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_010058295.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IMY1.1 GenPept UniProtKB/Swiss-Prot:Q6IMY1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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