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Arhgap22 Rho GTPase activating protein 22 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306279, updated on 2-Nov-2024

Summary

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Official Symbol
Arhgap22provided by RGD
Official Full Name
Rho GTPase activating protein 22provided by RGD
Primary source
RGD:1307237
See related
EnsemblRapid:ENSRNOG00000024728 AllianceGenome:RGD:1307237
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction and regulation of postsynapse organization. Predicted to be active in glutamatergic synapse. Orthologous to human ARHGAP22 (Rho GTPase activating protein 22). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 32.0), Lung (RPKM 18.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgap22 in Genome Data Viewer
Location:
16p16
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (8480222..8637823)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (8473806..8631552)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (9454269..9613508)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene WDFY family member 4 Neighboring gene leucine rich repeat containing 18 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134482457 Neighboring gene mitogen-activated protein kinase 8 Neighboring gene FERM and PDZ domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPδ and RhoGAP2. Valnegri P, et al. Hum Mol Genet, 2011 Dec 15. PMID 21926414, Free PMC Article
  2. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107297.1 → NP_001100767.1  rho GTPase-activating protein 22

    Status: PROVISIONAL

    Source sequence(s)
    CH474046
    UniProtKB/TrEMBL
    A6KFU6, D4ABZ7
    Related
    ENSRNOP00000033034.2, ENSRNOT00000035915.4
    Conserved Domains (4) summary
    pfam00169
    Location:29 → 54
    PH; PH domain
    pfam15035
    Location:437 → 529
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cl02570
    Location:61 → 190
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl17171
    Location:18 → 61
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    8480222..8637823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275358.1 → XP_063131428.1  rho GTPase-activating protein 22 isoform X3

    Related
    ENSRNOP00000096403.2, ENSRNOT00000101853.2

  2. XM_039094464.2 → XP_038950392.1  rho GTPase-activating protein 22 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZKJ1, A0A8I6APD0
    Conserved Domains (3) summary
    cd04390
    Location:173 → 371
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    TIGR02168
    Location:614 → 704
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:42 → 157
    PH-like; Pleckstrin homology-like domain

  3. XM_017600084.3 → XP_017455573.1  rho GTPase-activating protein 22 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZKJ1
    Conserved Domains (4) summary
    cd04390
    Location:157 → 355
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam00169
    Location:44 → 150
    PH; PH domain
    pfam15035
    Location:602 → 694
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cl17171
    Location:42 → 157
    PH-like; Pleckstrin homology-like domain

  4. XM_063275360.1 → XP_063131430.1  rho GTPase-activating protein 22 isoform X7

  5. XM_039094467.2 → XP_038950395.1  rho GTPase-activating protein 22 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZKJ1
    Related
    ENSRNOP00000068839.2, ENSRNOT00000082208.3
    Conserved Domains (3) summary
    cd04390
    Location:167 → 365
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    TIGR02168
    Location:608 → 698
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:36 → 151
    PH-like; Pleckstrin homology-like domain

  6. XM_063275359.1 → XP_063131429.1  rho GTPase-activating protein 22 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JTT7

  7. XM_063275361.1 → XP_063131431.1  rho GTPase-activating protein 22 isoform X8

  8. XM_039094469.2 → XP_038950397.1  rho GTPase-activating protein 22 isoform X6

    Conserved Domains (2) summary
    TIGR02168
    Location:397 → 487
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl02570
    Location:1 → 154
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  9. XM_006252751.5 → XP_006252813.1  rho GTPase-activating protein 22 isoform X5

    Conserved Domains (2) summary
    cd04390
    Location:33 → 231
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam15035
    Location:478 → 570
    Rootletin; Ciliary rootlet component, centrosome cohesion
Nucleotide Protein Strain
Heading Accession and Version

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