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Dennd6a DENN domain containing 6A [ Rattus norvegicus (Norway rat) ]

Gene ID: 306229, updated on 27-Nov-2024

Summary

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Official Symbol
Dennd6aprovided by RGD
Official Full Name
DENN domain containing 6Aprovided by RGD
Primary source
RGD:1306064
See related
EnsemblRapid:ENSRNOG00000011636 AllianceGenome:RGD:1306064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam116a; RGD1306064
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of cell-cell adhesion mediated by cadherin. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Predicted to be active in recycling endosome. Orthologous to human DENND6A (DENN domain containing 6A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 185.4), Thymus (RPKM 167.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dennd6a in Genome Data Viewer
Location:
16p16
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (1843803..1892165)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (1837019..1885420)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (2278701..2327062)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene sarcolemma associated protein Neighboring gene small nucleolar RNA SNORA71 Neighboring gene ribosomal protein L34, pseudogene 9 Neighboring gene uncharacterized LOC134482439 Neighboring gene ARF GTPase 4 Neighboring gene phosphodiesterase 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells. Linford A, et al. Dev Cell, 2012 May 15. PMID 22595670, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein DENND6A
Names
DENN/MADD domain containing 6A
family with sequence similarity 116, member A
hypothetical protein MGC38041

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134467.1 → NP_001127939.1  protein DENND6A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    D4A544
    Related
    ENSRNOP00000016233.5, ENSRNOT00000016233.7
    Conserved Domains (2) summary
    pfam08616
    Location:264 → 367
    SPA; Stabilization of polarity axis
    cl11519
    Location:168 → 353
    DENN; DENN (AEX-3) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    1843803..1892165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094441.2 → XP_038950369.1  protein DENND6A isoform X1

    Related
    ENSRNOP00000107624.1, ENSRNOT00000142051.1
    Conserved Domains (3) summary
    cl11519
    Location:168 → 353
    DENN; DENN (AEX-3) domain
    cl40631
    Location:264 → 367
    SPA; Stabilization of polarity axis
    cl40632
    Location:61 → 198
    Avl9; Transport protein Avl9

  2. XM_017600075.2 → XP_017455564.1  protein DENND6A isoform X2

    Related
    ENSRNOP00000110826.1, ENSRNOT00000156954.1

RNA

  1. XR_010058291.1 RNA Sequence

  2. XR_005494603.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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