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Gpc5 glypican 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306157, updated on 9-Dec-2024

Summary

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Official Symbol
Gpc5provided by RGD
Official Full Name
glypican 5provided by RGD
Primary source
RGD:1308835
See related
EnsemblRapid:ENSRNOG00000071105 AllianceGenome:RGD:1308835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in regulation of signal transduction. Predicted to be located in collagen-containing extracellular matrix; plasma membrane; and side of membrane. Orthologous to human GPC5 (glypican 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 101.8), Thymus (RPKM 11.6) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Gpc5 in Genome Data Viewer
Location:
15q23-q24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (98614499..100051285)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (92207275..93644054)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (100283131..101776838)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548462 Neighboring gene 40S ribosomal protein S16-like Neighboring gene microRNA 19b-1 Neighboring gene microRNA 92a-1 Neighboring gene uncharacterized LOC134482015 Neighboring gene uncharacterized LOC134482016 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene 60S ribosomal protein L10-like Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120097177 Neighboring gene uncharacterized LOC134482019 Neighboring gene uncharacterized LOC134482018 Neighboring gene glypican 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Williams EH, et al. Proc Natl Acad Sci U S A, 2010 Mar 30. PMID 20231458, Free PMC Article
  2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glypican-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107285.2 → NP_001100755.2  glypican-5 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A8I6ACQ6
    Related
    ENSRNOP00000104282.1, ENSRNOT00000161833.1
    Conserved Domains (1) summary
    pfam01153
    Location:12 → 569
    Glypican; Glypican

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    98614499..100051285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093413.2 → XP_038949341.1  glypican-5 isoform X2

    Conserved Domains (1) summary
    pfam01153
    Location:1 → 497
    Glypican

  2. XM_039093414.2 → XP_038949342.1  glypican-5 isoform X2

    Conserved Domains (1) summary
    pfam01153
    Location:1 → 497
    Glypican

  3. XM_063274345.1 → XP_063130415.1  glypican-5 isoform X2

  4. XM_039093412.2 → XP_038949340.1  glypican-5 isoform X1

    UniProtKB/TrEMBL
    A6HUE6
    Conserved Domains (1) summary
    pfam01153
    Location:93 → 496
    Glypican
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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