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Slitrk1 SLIT and NTRK-like family, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306147, updated on 27-Nov-2024

Summary

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Official Symbol
Slitrk1provided by RGD
Official Full Name
SLIT and NTRK-like family, member 1provided by RGD
Primary source
RGD:1308858
See related
EnsemblRapid:ENSRNOG00000009209 AllianceGenome:RGD:1308858
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Involved in regulation of synapse organization. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and trichotillomania. Orthologous to human SLITRK1 (SLIT and NTRK like family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See Slitrk1 in Genome Data Viewer
Location:
15q23
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (92137703..92141741, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (85723252..85727290, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (93303382..93307420, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene MLV-related proviral Env polyprotein-like, pseudogene 8 Neighboring gene apolipoprotein O-like, pseudogene 2 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of SLITRK1 variation in obsessive-compulsive disorder. Ozomaro U, et al. PLoS One, 2013. PMID 23990902, Free PMC Article
  2. Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities. Katayama K, et al. Mol Psychiatry, 2010 Feb. PMID 18794888
  3. Slitrk1 is localized to excitatory synapses and promotes their development. Beaubien F, et al. Sci Rep, 2016 Jun 7. PMID 27273464, Free PMC Article
  4. A Modular Organization of LRR Protein-Mediated Synaptic Adhesion Defines Synapse Identity. Schroeder A, et al. Neuron, 2018 Jul 25. PMID 29983322
  5. Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases. Yim YS, et al. Proc Natl Acad Sci U S A, 2013 Mar 5. PMID 23345436, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within adult behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axonogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homeostatic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nervous system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron projection extension ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within norepinephrine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of presynapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic membrane adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vocalization behavior ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SLIT and NTRK-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107283.1 → NP_001100753.1  SLIT and NTRK-like protein 1 precursor

    See identical proteins and their annotated locations for NP_001100753.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473951
    UniProtKB/TrEMBL
    A6HUD1, D3Z8D8
    Related
    ENSRNOP00000012195.5, ENSRNOT00000012195.7
    Conserved Domains (3) summary
    sd00033
    Location:62 → 83
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:425 → 483
    LRR_8; Leucine rich repeat
    cl15307
    Location:212 → 250
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    92137703..92141741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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