U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pspc1 paraspeckle component 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305910, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Pspc1provided by RGD
Official Full Name
paraspeckle component 1provided by RGD
Primary source
RGD:1310122
See related
EnsemblRapid:ENSRNOG00000020782 AllianceGenome:RGD:1310122
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity. Predicted to be involved in several processes, including activation of innate immune response; negative regulation of DNA-templated transcription; and regulation of circadian rhythm. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in paraspeckles. Orthologous to human PSPC1 (paraspeckle component 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 212.3), Spleen (RPKM 189.4) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pspc1 in Genome Data Viewer
Location:
15p12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (34941445..35027460, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (30828617..30911315, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (36946914..37030273, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) polymerase family, member 4 Neighboring gene small nucleolar RNA SNORA5 Neighboring gene M-phase phosphoprotein 8 Neighboring gene zinc finger MYM-type containing 5 Neighboring gene ribosomal protein L39, pseudogene 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult. Zhang B, et al. Cell Rep, 2012 Jul 26. PMID 22840402, Free PMC Article
  2. Distinct roles of DBHS family members in the circadian transcriptional feedback loop. Kowalska E, et al. Mol Cell Biol, 2012 Nov. PMID 22966205, Free PMC Article
  3. An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles. Clemson CM, et al. Mol Cell, 2009 Mar 27. PMID 19217333, Free PMC Article
  4. HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response. Morchikh M, et al. Mol Cell, 2017 Aug 3. PMID 28712728
  5. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC116378

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in membraneless organelle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in paraspeckles ISO
Inferred from Sequence Orthology
more info
  
located_in paraspeckles ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
paraspeckle component 1
Names
paraspeckle protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025672.2 → NP_001020843.1  paraspeckle component 1

    See identical proteins and their annotated locations for NP_001020843.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    Q4KLH4
    UniProtKB/TrEMBL
    A0A8I6ATP2, A6KHA3
    Related
    ENSRNOP00000028219.4, ENSRNOT00000028219.8
    Conserved Domains (3) summary
    cd12949
    Location:226 → 319
    NOPS_PSPC1; NOPS domain, including C-terminal coiled-coil region, in paraspeckle protein component 1 (PSPC1) and similar proteins
    cd12586
    Location:80 → 150
    RRM1_PSP1; RNA recognition motif 1 in vertebrate paraspeckle protein 1 (PSP1)
    cd12589
    Location:156 → 235
    RRM2_PSP1; RNA recognition motif 2 in vertebrate paraspeckle protein 1 (PSP1 or PSPC1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    34941445..35027460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093317.2 → XP_038949245.1  paraspeckle component 1 isoform X3

    Conserved Domains (2) summary
    cl06904
    Location:226 → 318
    eNOPS_SF; NOPS domain, including C-terminal helical extension region, in the p54nrb/PSF/PSP1 family
    cl17169
    Location:156 → 235
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_039093316.2 → XP_038949244.1  paraspeckle component 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JYN7, A0A8I6ATP2
    Conserved Domains (3) summary
    cd12946
    Location:226 → 318
    NOPS_p54nrb_PSF_PSPC1; NOPS domain, including C-terminal coiled-coil region, in p54nrb/PSF/PSPC1 family proteins
    cd12586
    Location:80 → 150
    RRM1_PSP1; RNA recognition motif 1 (RRM1) found in vertebrate paraspeckle protein 1 (PSP1)
    cl17169
    Location:156 → 235
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_063274262.1 → XP_063130332.1  paraspeckle component 1 isoform X1

    UniProtKB/Swiss-Prot
    Q4KLH4
    UniProtKB/TrEMBL
    A0A8I6ATP2, A6KHA3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KLH4.1 GenPept UniProtKB/Swiss-Prot:Q4KLH4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools