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lcp1 lymphocyte cytosolic protein 1 (L-plastin) [ Danio rerio (zebrafish) ]

Gene ID: 30583, updated on 12-Jan-2025

Summary

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Official Symbol
lcp1provided by ZNC
Official Full Name
lymphocyte cytosolic protein 1 (L-plastin)provided by ZNC
Primary source
ZFIN:ZDB-GENE-991213-5
See related
Ensembl:ENSDARG00000023188 AllianceGenome:ZFIN:ZDB-GENE-991213-5
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb245; fj24b12; wu:fj24b12
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly and actin filament network formation. Located in cytoplasm. Is expressed in several structures, including eye; hematopoietic cell; hematopoietic system; mesoderm; and renal system. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human LCP1 (lymphocyte cytosolic protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See lcp1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (56251000..56272465, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (56663225..56670983, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496516 Neighboring gene TBC1 domain family member 8 Neighboring gene ribosomal protein L31 Neighboring gene CCR4-NOT transcription complex, subunit 11 Neighboring gene uncharacterized LOC110440053 Neighboring gene uncharacterized LOC101885626

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. An Integrated Approach for a Structural and Functional Evaluation of Biosimilars: Implications for Erythropoietin. Gianoncelli A, et al. BioDrugs, 2015 Aug. PMID 26334631, Free PMC Article
  2. Imaging macrophage chemotaxis in vivo: studies of microtubule function in zebrafish wound inflammation. Redd MJ, et al. Cell Motil Cytoskeleton, 2006 Jul. PMID 16671106
  3. Identification of regulatory elements recapitulating early expression of L-plastin in the zebrafish enveloping layer and embryonic periderm. Baumgartner EA, et al. Gene Expr Patterns, 2019 Jun. PMID 30940554, Free PMC Article
  4. An Optimized Small Tissue Handling System for Immunohistochemistry and In Situ Hybridization. Anthony G, et al. PLoS One, 2016. PMID 27489962, Free PMC Article
  5. The adapter protein Myd88 plays an important role in limiting mycobacterial growth in a zebrafish model for tuberculosis. Hosseini R, et al. Virchows Arch, 2021 Aug. PMID 33559740, Free PMC Article

See all (286) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actin filament bundle assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament network formation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in actin filament bundle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
plastin-2
Names
L-plastin
leucocyte-specific plastin 1
lymphocyte cytosolic plastin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131320.3 → NP_571395.2  plastin-2

    See identical proteins and their annotated locations for NP_571395.2

    Status: VALIDATED

    Source sequence(s)
    CU914623, FO905030
    UniProtKB/Swiss-Prot
    Q6P698, Q9W746
    UniProtKB/TrEMBL
    A0A140LGK1, A0A140LGV0, A0A8N7UZJ0
    Related
    ENSDARP00000142380.2, ENSDART00000039235.8
    Conserved Domains (4) summary
    smart00033
    Location:396 → 499
    CH; Calponin homology domain
    cd00014
    Location:119 → 234
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:13 → 79
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:14 → 78
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    56251000..56272465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223284.1 → XP_068079385.1  plastin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q6P698, Q9W746
    UniProtKB/TrEMBL
    A0A140LGK1, A0A140LGV0, A0A8N7UZJ0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P698.1 GenPept UniProtKB/Swiss-Prot:Q6P698

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials