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hsp90ab1 heat shock protein 90, alpha (cytosolic), class B member 1 [ Danio rerio (zebrafish) ]

Gene ID: 30573, updated on 9-Dec-2024

Summary

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Official Symbol
hsp90ab1provided by ZNC
Official Full Name
heat shock protein 90, alpha (cytosolic), class B member 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-95
See related
Ensembl:ENSDARG00000029150 AllianceGenome:ZFIN:ZDB-GENE-990415-95
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hsp90b; hsp90beta; wu:fa29f01; wu:fa91e11; wu:fd59e11; wu:gcd22h07
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and receptor ligand inhibitor activity. Acts upstream of or within blood vessel development and leukocyte migration. Predicted to be located in dynein axonemal particle; extracellular region; and nucleus. Predicted to be part of aryl hydrocarbon receptor complex. Predicted to be active in cytosol; perinuclear region of cytoplasm; and plasma membrane. Is expressed in eye and head. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to several human genes including HSP90AB1 (heat shock protein 90 alpha family class B member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See hsp90ab1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (51198445..51211840)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (51385225..51398620)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2, subunit 1 alpha b Neighboring gene RNA binding motif protein 25b Neighboring gene solute carrier family 35 member B2 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Vibsanin B preferentially targets HSP90β, inhibits interstitial leukocyte migration, and ameliorates experimental autoimmune encephalomyelitis. Ye BX, et al. J Immunol, 2015 May 1. PMID 25810397
  2. The molecular characterization and expression of heat shock protein 90 (Hsp90) and 26 (Hsp26) cDNAs in sea cucumber (Apostichopus japonicus). Zhao H, et al. Cell Stress Chaperones, 2011 Sep. PMID 21484287, Free PMC Article
  3. A comparison of Hsp90alpha and Hsp90beta interactions with cochaperones and substrates. Taherian A, et al. Biochem Cell Biol, 2008 Feb. PMID 18364744
  4. Specific localization of zebrafish hsp90 alpha mRNA to myoD-expressing cells suggests a role for hsp90 alpha during normal muscle development. Sass JB, et al. Mech Dev, 1996 Feb. PMID 8652412
  5. The UCS factor Steif/Unc-45b interacts with the heat shock protein Hsp90a during myofibrillogenesis. Etard C, et al. Dev Biol, 2007 Aug 1. PMID 17586488

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HSP90beta prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53.
    Title: HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53.
  2. Data demonstrate that Hsp90alpha and Hsp90beta exhibit similar interactions with co-chaperones, but significantly different behaviors with respect to substrate interactions under stress conditions.
    Title: A comparison of Hsp90alpha and Hsp90beta interactions with cochaperones and substrates.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables receptor ligand inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to heat IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within leukocyte migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to estrogen ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of aryl hydrocarbon receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dynein axonemal particle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
heat shock protein HSP 90-beta
Names
heat shock protein 90-beta
heat shock protein 90kDa alpha (cytosolic), class B member 1
heat shock protein 90kDa alpha, class B member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131310.3 → NP_571385.2  heat shock protein HSP 90-beta

    See identical proteins and their annotated locations for NP_571385.2

    Status: VALIDATED

    Source sequence(s)
    BC065359, EH451195
    UniProtKB/Swiss-Prot
    O57521, Q6P0Y9, Q90475
    Related
    ENSDARP00000014978.8, ENSDART00000020084.10
    Conserved Domains (3) summary
    smart00387
    Location:34 → 185
    HATPase_c; Histidine kinase-like ATPases
    PTZ00272
    Location:13 → 725
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
    pfam00183
    Location:190 → 715
    HSP90; Hsp90 protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    51198445..51211840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O57521.2 GenPept UniProtKB/Swiss-Prot:O57521

Gene LinkOut

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