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Samd8 sterile alpha motif domain containing 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305684, updated on 27-Nov-2024

Summary

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Official Symbol
Samd8provided by RGD
Official Full Name
sterile alpha motif domain containing 8provided by RGD
Primary source
RGD:1306447
See related
EnsemblRapid:ENSRNOG00000013236 AllianceGenome:RGD:1306447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ceramide cholinephosphotransferase activity; ceramide phosphoethanolamine synthase activity; and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process and regulation of ceramide biosynthetic process. Predicted to act upstream of or within ceramide phosphoethanolamine biosynthetic process. Predicted to be located in cytosol and endoplasmic reticulum. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Orthologous to human SAMD8 (sterile alpha motif domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 243.1), Muscle (RPKM 199.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Samd8 in Genome Data Viewer
Location:
15p16
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (2561435..2611702, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (2512104..2562368, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (2685504..2731062, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482075 Neighboring gene catechol-O-methyltransferase domain containing 1 Neighboring gene voltage-dependent anion channel 2 Neighboring gene dual specificity phosphatase 13A Neighboring gene uncharacterized LOC108352868 Neighboring gene dual specificity phosphatase 13B Neighboring gene uncharacterized LOC120096899

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice. Bickert A, et al. J Lipid Res, 2015 Apr. PMID 25667419, Free PMC Article
  2. All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity. Ding T, et al. J Lipid Res, 2015 Mar. PMID 25605874, Free PMC Article
  3. Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. Vacaru AM, et al. J Cell Biol, 2009 Jun 15. PMID 19506037, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ceramide cholinephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide phosphoethanolamine synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables sphingomyelin synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ceramide phosphoethanolamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sphingomyelin synthase-related protein 1
NP_001012040.1
NP_001380764.1
XP_038949161.1
XP_063130265.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012040.2 → NP_001012040.1  sphingomyelin synthase-related protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001012040.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6KKT1, Q641X0
    Conserved Domains (2) summary
    cd09515
    Location:72 → 140
    SAM_SGMS1-like; SAM domain of sphingomyelin synthase related subfamily
    pfam14360
    Location:355 → 428
    PAP2_C; PAP2 superfamily C-terminal

  2. NM_001393835.1 → NP_001380764.1  sphingomyelin synthase-related protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A8I6ARL7, A6KKT1
    Related
    ENSRNOP00000100388.1, ENSRNOT00000018023.8
    Conserved Domains (2) summary
    cd09515
    Location:26 → 94
    SAM_SGMS1-like; SAM domain of sphingomyelin synthase related subfamily
    pfam14360
    Location:309 → 382
    PAP2_C; PAP2 superfamily C-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    2561435..2611702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093233.2 → XP_038949161.1  sphingomyelin synthase-related protein 1 isoform X1

    UniProtKB/TrEMBL
    A6KKT1
    Conserved Domains (2) summary
    cd09515
    Location:9 → 77
    SAM_SGMS1-like; SAM domain of sphingomyelin synthase related subfamily
    pfam14360
    Location:292 → 365
    PAP2_C; PAP2 superfamily C-terminal

  2. XM_063274195.1 → XP_063130265.1  sphingomyelin synthase-related protein 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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